Reaction Details |
| Report a problem with these data |
Target | Prostaglandin G/H synthase 2 |
---|
Ligand | BDBM50172479 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_321346 (CHEMBL880660) |
---|
IC50 | 910.0±n/a nM |
---|
Citation | Peretto, I; Radaelli, S; Parini, C; Zandi, M; Raveglia, LF; Dondio, G; Fontanella, L; Misiano, P; Bigogno, C; Rizzi, A; Riccardi, B; Biscaioli, M; Marchetti, S; Puccini, P; Catinella, S; Rondelli, I; Cenacchi, V; Bolzoni, PT; Caruso, P; Villetti, G; Facchinetti, F; Del Giudice, E; Moretto, N; Imbimbo, BP Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. J Med Chem48:5705-20 (2005) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Prostaglandin G/H synthase 2 |
---|
Name: | Prostaglandin G/H synthase 2 |
Synonyms: | COX2 | Cyclooxygenase | Cyclooxygenase 2 (COX-2) | Cyclooxygenase-2 | Cyclooxygenase-2 (COX-2 AA) | Cyclooxygenase-2 (COX-2 AEA) | Cyclooxygenase-2 (COX-2) | PGH synthase 2 | PGH2_HUMAN | PGHS-2 | PHS II | PTGS2 | Prostaglandin E synthase/G/H synthase 2 | Prostaglandin H2 synthase 2 | Prostaglandin-endoperoxide synthase 2 |
Type: | Enzyme |
Mol. Mass.: | 69003.89 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant Cox-2 provided by Cayman (Cayman Chemical Co.,Ann Arbor, MI). |
Residue: | 604 |
Sequence: | MLARALLLCAVLALSHTANPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFL
TRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADY
GYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGS
NMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKY
QIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCD
VLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQ
NRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRV
AGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEAL
YGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEV
GFQIINTASIQSLICNNVKGCPFTSFSVPDPELIKTVTINASSSRSGLDDINPTVLLKER
STEL
|
|
|
BDBM50172479 |
---|
n/a |
---|
Name | BDBM50172479 |
Synonyms: | (S)-FLURBIPROFEN | CHEMBL435298 |
Type | Small organic molecule |
Emp. Form. | C15H13FO2 |
Mol. Mass. | 244.2609 |
SMILES | C[C@H](C(O)=O)c1ccc(c(F)c1)-c1ccccc1 |
Structure |
|