| Reaction Details |
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 | Report a problem with these data |
| Target | Prostaglandin G/H synthase 1 |
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| Ligand | BDBM50172479 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_321330 (CHEMBL880614) |
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| IC50 | 30±n/a nM |
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| Citation |  Peretto, I; Radaelli, S; Parini, C; Zandi, M; Raveglia, LF; Dondio, G; Fontanella, L; Misiano, P; Bigogno, C; Rizzi, A; Riccardi, B; Biscaioli, M; Marchetti, S; Puccini, P; Catinella, S; Rondelli, I; Cenacchi, V; Bolzoni, PT; Caruso, P; Villetti, G; Facchinetti, F; Del Giudice, E; Moretto, N; Imbimbo, BP Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. J Med Chem48:5705-20 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Prostaglandin G/H synthase 1 |
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| Name: | Prostaglandin G/H synthase 1 |
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| Synonyms: | Cox-1 | Cox1 | Cyclooxygenase | Cyclooxygenase-1 | PGH1_RAT | Prostaglandin G/H synthase (cyclooxygenase) | Ptgs1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 69033.56 |
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| Organism: | RAT |
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| Description: | COX-1 0 RAT::Q63921 |
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| Residue: | 602 |
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| Sequence: | MSRRSLSLQFPLLLLLLLLPPPPVLLTDAGVPSPVNPCCYYPCQNQGVCVRFGLDHYQCD
CTRTGYSGPNCTIPEIWTWLRSSLRPSPSFTHFLLTHGYWIWEFVNATFIREVLMRLVIT
VRSNLIPSPPTYNTAHDYISWESFSNVSYYTRILPSVPKDCPTPMGTKGKKQLPDIHLLA
QRLLLRREFIPGPQGTNVLFAFFAQHFTHQFFKTSGKMGPGFTKALGHGVDLGHIYGDSL
ERQYHLRLFKDGKLKYQVLDGEVYPPSVEQASVLMRYPPGVPPEKQMAVGQEVFGLLPGL
MLFSTIWLREHNRVCDLLKEEHPTWDDEQLFQTTRLILIGETIKIIIEEYVQHLSGYFLQ
LKFDPELLFRAQFQYRNRIALEFNHLYHWHPLMPDSFQVGSQEYSYEQFLFNTSMLVDYG
VEALVDAFSRQRAGRIGGGRNFDYHVLHVAEDVIKESREMRLQSFNEYRKRFGLKPYTSF
QEFTGEKEMAAELEELYGDIDALEFYPGLMLEKCQPNSLFGESMIEMGAPFSLKGLLGNP
ICSPEYWKPSTFGGDVGFNIVNTASLKKLVCLNTKTCPYVSFRVPDYPGDDGSVFVRPST
EL
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| BDBM50172479 |
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| n/a |
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| Name | BDBM50172479 |
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| Synonyms: | (S)-FLURBIPROFEN | CHEMBL435298 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H13FO2 |
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| Mol. Mass. | 244.2609 |
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| SMILES | C[C@H](C(O)=O)c1ccc(c(F)c1)-c1ccccc1 |
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| Structure | 
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