| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase/RNaseH |
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| Ligand | BDBM50172746 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_321416 (CHEMBL881947) |
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| IC50 | 500±n/a nM |
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| Citation |  Bedoya, LM; Beltrán, M; Sancho, R; Olmedo, DA; Sánchez-Palomino, S; del Olmo, E; López-Pérez, JL; Muñoz, E; San Feliciano, A; Alcamí, J 4-Phenylcoumarins as HIV transcription inhibitors. Bioorg Med Chem Lett15:4447-50 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Reverse transcriptase/RNaseH |
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| Name: | Reverse transcriptase/RNaseH |
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| Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65229.15 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_1473730 |
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| Residue: | 566 |
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| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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| BDBM50172746 |
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| n/a |
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| Name | BDBM50172746 |
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| Synonyms: | 5,7-Dihydroxy-8-(2-hydroxy-3-methyl-but-2-enyl)-6-(3-methyl-butyryl)-4-phenyl-chromen-2-one | CHEMBL199090 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H26O6 |
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| Mol. Mass. | 422.4703 |
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| SMILES | CC(C)CC(=O)c1c(O)c(CC(=O)C(C)C)c2oc(=O)cc(-c3ccccc3)c2c1O |
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| Structure | 
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