| Reaction Details |
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 | Report a problem with these data |
| Target | Sigma non-opioid intracellular receptor 1 |
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| Ligand | BDBM50172915 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_321533 (CHEMBL880593) |
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| IC50 | 77±n/a nM |
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| Citation |  Charton, J; Cazenave Gassiot, A; Girault-Mizzi, S; Debreu-Fontaine, MA; Melnyk, P; Sergheraert, C Synthesis and pharmacological evaluation of Tic-hydantoin derivatives as selective sigma1 ligands. Part 1. Bioorg Med Chem Lett15:4833-7 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sigma non-opioid intracellular receptor 1 |
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| Name: | Sigma non-opioid intracellular receptor 1 |
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| Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 25124.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q99720 |
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| Residue: | 223 |
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| Sequence: | MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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| BDBM50172915 |
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| n/a |
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| Name | BDBM50172915 |
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| Synonyms: | (S)-2-(2-Piperidin-1-yl-ethyl)-1,2,3,5,10,10a-hexahydro-imidazo[1,5-b]isoquinoline | CHEMBL383147 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H27N3 |
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| Mol. Mass. | 285.4271 |
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| SMILES | C(CN1CCCCC1)N1C[C@@H]2Cc3ccccc3CN2C1 |
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| Structure | 
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