| Reaction Details |
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 | Report a problem with these data |
| Target | Delta-type opioid receptor |
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| Ligand | BDBM50173246 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_321479 (CHEMBL880420) |
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| IC50 | >10000±n/a nM |
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| Citation |  Bignan, GC; Battista, K; Connolly, PJ; Orsini, MJ; Liu, J; Middleton, SA; Reitz, AB Preparation of 3-spirocyclic indolin-2-ones as ligands for the ORL-1 receptor. Bioorg Med Chem Lett15:5022-6 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Delta-type opioid receptor |
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| Name: | Delta-type opioid receptor |
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| Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 40382.98 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
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| Residue: | 372 |
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| Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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| BDBM50173246 |
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| n/a |
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| Name | BDBM50173246 |
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| Synonyms: | 1'-cyclooctylmethyl-5-isopropyl-1-methylspiro[2,3-dihydro-1H-indole-3,4'-(hexahydropyridine)]-2-one | CHEMBL197895 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H38N2O |
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| Mol. Mass. | 382.582 |
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| SMILES | CC(C)c1ccc2N(C)C(=O)C3(CCN(CC4CCCCCCC4)CC3)c2c1 |
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| Structure | 
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