| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 5 |
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| Ligand | BDBM50173393 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_321534 (CHEMBL880594) |
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| IC50 | 7.1±n/a nM |
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| Citation |  Cumming, JG; Cooper, AE; Grime, K; Logan, CJ; McLaughlin, S; Oldfield, J; Shaw, JS; Tucker, H; Winter, J; Whittaker, D Modulators of the human CCR5 receptor. Part 2: SAR of substituted 1-(3,3-diphenylpropyl)-piperidinyl phenylacetamides. Bioorg Med Chem Lett15:5012-5 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 5 |
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| Name: | C-C chemokine receptor type 5 |
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| Synonyms: | C-C CKR-5 | C-C chemokine receptor type 5 | CC-CKR-5 | CCR-5 | CCR5 | CCR5/mu opioid receptor complex | CCR5_HUMAN | CD_antigen=CD195 | CHEMR13 | CMKBR5 | HIV-1 fusion coreceptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 40540.21 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51681 |
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| Residue: | 352 |
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| Sequence: | MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKR
LKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
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| BDBM50173393 |
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| n/a |
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| Name | BDBM50173393 |
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| Synonyms: | 4-[3-(4-{Ethyl-[2-(4-methanesulfonyl-phenyl)-acetyl]-amino}-piperidin-1-yl)-1-phenyl-propyl]-benzoic acid methyl ester | CHEMBL197680 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H40N2O5S |
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| Mol. Mass. | 576.746 |
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| SMILES | CCN(C1CCN(CCC(c2ccccc2)c2ccc(cc2)C(=O)OC)CC1)C(=O)Cc1ccc(cc1)S(C)(=O)=O |
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| Structure | 
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