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TargetMelanin-concentrating hormone receptor 1
LigandBDBM50173455
Substrate/Competitorn/a
Meas. Tech.ChEMBL_321503 (CHEMBL880563)
IC50 60±n/a nM
Citation Kym, PRIyengar, RSouers, AJLynch, JKJudd, ASGao, JFreeman, JMulhern, MZhao, GVasudevan, AWodka, DBlackburn, CBrown, JChe, JLCullis, CLai, SJLaMarche, MJMarsilje, TRoses, JSells, TGeddes, BGovek, EPatane, MFry, DDayton, BDBrodjian, SFalls, DBrune, MBush, EShapiro, RKnourek-Segel, VFey, TMcDowell, CReinhart, GAPreusser, LCMarsh, KHernandez, LSham, HLCollins, CA Discovery and characterization of aminopiperidinecoumarin melanin concentrating hormone receptor 1 antagonists. J Med Chem48:5888-91 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Melanin-concentrating hormone receptor 1
Name:Melanin-concentrating hormone receptor 1
Synonyms:G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:45976.27
Organism:Homo sapiens (Human)
Description:Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays.
Residue:422
Sequence:
MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARL
WEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTIC
LLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHF
GETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALS
FISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRI
LQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVY
LYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESK
GT
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BDBM50173455
n/a
NameBDBM50173455
Synonyms:6-Chloro-4-[1-(1-methyl-1H-indol-6-ylmethyl)-piperidin-4-ylamino]-chromen-2-one | CHEMBL371877
TypeSmall organic molecule
Emp. Form.C24H24ClN3O2
Mol. Mass.421.919
SMILESCn1ccc2ccc(CN3CCC(CC3)Nc3cc(=O)oc4ccc(Cl)cc34)cc12
Structure
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