| Reaction Details |
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 | Report a problem with these data |
| Target | Melanin-concentrating hormone receptor 1 |
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| Ligand | BDBM50173465 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_322396 (CHEMBL871872) |
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| IC50 | 44±n/a nM |
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| Citation |  Kym, PR; Iyengar, R; Souers, AJ; Lynch, JK; Judd, AS; Gao, J; Freeman, J; Mulhern, M; Zhao, G; Vasudevan, A; Wodka, D; Blackburn, C; Brown, J; Che, JL; Cullis, C; Lai, SJ; LaMarche, MJ; Marsilje, T; Roses, J; Sells, T; Geddes, B; Govek, E; Patane, M; Fry, D; Dayton, BD; Brodjian, S; Falls, D; Brune, M; Bush, E; Shapiro, R; Knourek-Segel, V; Fey, T; McDowell, C; Reinhart, GA; Preusser, LC; Marsh, K; Hernandez, L; Sham, HL; Collins, CA Discovery and characterization of aminopiperidinecoumarin melanin concentrating hormone receptor 1 antagonists. J Med Chem48:5888-91 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanin-concentrating hormone receptor 1 |
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| Name: | Melanin-concentrating hormone receptor 1 |
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| Synonyms: | G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 45976.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays. |
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| Residue: | 422 |
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| Sequence: | MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARL
WEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTIC
LLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHF
GETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALS
FISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRI
LQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVY
LYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESK
GT
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| BDBM50173465 |
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| n/a |
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| Name | BDBM50173465 |
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| Synonyms: | 6-Methoxy-4-[1-(3-phenyl-allyl)-piperidin-4-ylamino]-chromen-2-one | CHEMBL194576 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H26N2O3 |
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| Mol. Mass. | 390.4748 |
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| SMILES | COc1ccc2oc(=O)cc(NC3CCN(C\C=C\c4ccccc4)CC3)c2c1 |
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| Structure | 
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