| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Melanin-concentrating hormone receptor 1 |
|---|
| Ligand | BDBM50173453 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_321503 (CHEMBL880563) |
|---|
| IC50 | 19±n/a nM |
|---|
| Citation |  Kym, PR; Iyengar, R; Souers, AJ; Lynch, JK; Judd, AS; Gao, J; Freeman, J; Mulhern, M; Zhao, G; Vasudevan, A; Wodka, D; Blackburn, C; Brown, J; Che, JL; Cullis, C; Lai, SJ; LaMarche, MJ; Marsilje, T; Roses, J; Sells, T; Geddes, B; Govek, E; Patane, M; Fry, D; Dayton, BD; Brodjian, S; Falls, D; Brune, M; Bush, E; Shapiro, R; Knourek-Segel, V; Fey, T; McDowell, C; Reinhart, GA; Preusser, LC; Marsh, K; Hernandez, L; Sham, HL; Collins, CA Discovery and characterization of aminopiperidinecoumarin melanin concentrating hormone receptor 1 antagonists. J Med Chem48:5888-91 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Melanin-concentrating hormone receptor 1 |
|---|
| Name: | Melanin-concentrating hormone receptor 1 |
|---|
| Synonyms: | G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 45976.27 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays. |
|---|
| Residue: | 422 |
|---|
| Sequence: | MSVGAMKKGVGRAVGLGGGSGCQATEEDPLPNCGACAPGQGGRRWRLPQPAWVEGSSARL
WEQATGTGWMDLEASLLPTGPNASNTSDGPDNLTSAGSPPRTGSISYINIIMPSVFGTIC
LLGIIGNSTVIFAVVKKSKLHWCNNVPDIFIINLSVVDLLFLLGMPFMIHQLMGNGVWHF
GETMCTLITAMDANSQFTSTYILTAMAIDRYLATVHPISSTKFRKPSVATLVICLLWALS
FISITPVWLYARLIPFPGGAVGCGIRLPNPDTDLYWFTLYQFFLAFALPFVVITAAYVRI
LQRMTSSVAPASQRSIRLRTKRVTRTAIAICLVFFVCWAPYYVLQLTQLSISRPTLTFVY
LYNAAISLGYANSCLNPFVYIVLCETFRKRLVLSVKPAAQGQLRAVSNAQTADEERTESK
GT
|
|
|
|---|
| BDBM50173453 |
|---|
| n/a |
|---|
| Name | BDBM50173453 |
|---|
| Synonyms: | 6-Chloro-4-[1-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperidin-4-ylamino]-chromen-2-one | CHEMBL194292 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H19ClF2N2O4 |
|---|
| Mol. Mass. | 448.847 |
|---|
| SMILES | FC1(F)Oc2ccc(CN3CCC(CC3)Nc3cc(=O)oc4ccc(Cl)cc34)cc2O1 |
|---|
| Structure | 
|
|---|
Search and Browse
