Reaction Details |
| Report a problem with these data |
Target | Reverse transcriptase/RNaseH |
---|
Ligand | BDBM2809 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_321537 (CHEMBL880597) |
---|
IC50 | 74±n/a nM |
---|
Citation | Deng, BL; Hartman, TL; Buckheit, RW; Pannecouque, C; De Clercq, E; Fanwick, PE; Cushman, M Synthesis, anti-HIV activity, and metabolic stability of new alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors. J Med Chem48:6140-55 (2005) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Reverse transcriptase/RNaseH |
---|
Name: | Reverse transcriptase/RNaseH |
Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
Type: | PROTEIN |
Mol. Mass.: | 65229.15 |
Organism: | Human immunodeficiency virus 1 |
Description: | ChEMBL_1473730 |
Residue: | 566 |
Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
|
|
|
BDBM2809 |
---|
n/a |
---|
Name | BDBM2809 |
Synonyms: | Alkenyldiarylmethanes (ADAM) 6b | CHEMBL105859 | Methyl (5Z)-6-(3,4-dimethoxyphenyl)-6-[4-methoxy-3-(methoxycarbonyl)-5-methylphenyl]hex-5-enoate | methyl 5-[(1E)-1-(3,4-dimethoxyphenyl)-6-methoxy-6-oxohex-1-en-1-yl]-2-methoxy-3-methylbenzoate |
Type | Small organic molecule |
Emp. Form. | C25H30O7 |
Mol. Mass. | 442.5015 |
SMILES | COC(=O)CCC\C=C(\c1ccc(OC)c(OC)c1)c1cc(C)c(OC)c(c1)C(=O)OC |
Structure |
|