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TargetMitogen-activated protein kinase kinase kinase 8
LigandBDBM50173834
Substrate/Competitorn/a
Meas. Tech.ChEMBL_326807 (CHEMBL860389)
IC50 12±n/a nM
Citation Gavrin, LKGreen, NHu, YJanz, KKaila, NLi, HQTam, SYThomason, JRGopalsamy, ACiszewski, GCuozzo, JWHall, JPHsu, STelliez, JBLin, LL Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships. Bioorg Med Chem Lett15:5288-92 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase kinase kinase 8
Name:Mitogen-activated protein kinase kinase kinase 8
Synonyms:C-COT | COT | COT proto-oncogene serine/threonine-protein kinase | Cancer Osaka thyroid oncogene | ESTF | M3K8_HUMAN | MAP3K8 | Tpl-2 | Tumor Progression Loci-2 Kinase (COT) | Tumor progression locus 2
Type:Serine/threonine-protein kinase
Mol. Mass.:52916.89
Organism:Homo sapiens (Human)
Description:P41279
Residue:467
Sequence:
MEYMSTGSDNKEEIDLLIKHLNVSDVIDIMENLYASEEPAVYEPSLMTMCQDSNQNDERS
KSLLLSGQEVPWLSSVRYGTVEDLLAFANHISNTAKHFYGQRPQESGILLNMVITPQNGR
YQIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVE
IQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKG
LDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVIL
CRGHSTKADIYSLGATLIHMQTGTPPWVKRYPRSAYPSYLYIIHKQAPPLEDIADDCSPG
MRELIEASLERNPNHRPRAADLLKHEALNPPREDQPRCQSLDSALLERKRLLSRKELELP
ENIADSSCTGSTEESEMLKRQRSLYIDLGALAGYFNLVRGPPTLEYG
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  Blast E-value cutoff:
BDBM50173834
n/a
NameBDBM50173834
Synonyms:(R)-4-(3-chloro-4-fluorophenylamino)-6-(1-phenylethylamino)-1,7-naphthyridine-3-carbonitrile | CHEMBL199230
TypeSmall organic molecule
Emp. Form.C23H17ClFN5
Mol. Mass.417.866
SMILESC[C@@H](Nc1cc2c(Nc3ccc(F)c(Cl)c3)c(cnc2cn1)C#N)c1ccccc1 |r|
Structure
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