| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dual specificity mitogen-activated protein kinase kinase 1 |
|---|
| Ligand | BDBM29896 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_326808 (CHEMBL860398) |
|---|
| IC50 | 15000±n/a nM |
|---|
| Citation |  Gavrin, LK; Green, N; Hu, Y; Janz, K; Kaila, N; Li, HQ; Tam, SY; Thomason, JR; Gopalsamy, A; Ciszewski, G; Cuozzo, JW; Hall, JP; Hsu, S; Telliez, JB; Lin, LL Inhibition of Tpl2 kinase and TNF-alpha production with 1,7-naphthyridine-3-carbonitriles: synthesis and structure-activity relationships. Bioorg Med Chem Lett15:5288-92 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dual specificity mitogen-activated protein kinase kinase 1 |
|---|
| Name: | Dual specificity mitogen-activated protein kinase kinase 1 |
|---|
| Synonyms: | Dual specificity mitogen-activated protein kinase (MEK) | Dual specificity mitogen-activated protein kinase kinase 1 (MEK) | Dual specificity mitogen-activated protein kinase kinase 1 (MEK1) | Dual specificity mitogen-activated protein kinase kinase 1/Mitogen-activated protein kinase 1/RAF proto-oncogene serine/threonine-protein kinase | Dual specificity mitogen-activated protein kinase kinase MEK1/2 | ERK activator kinase 1 | MAP kinase kinase 1 | MAP2K1 | MAPK/ERK kinase 1 | MAPK/ERK kinase 1 (MEK1) | MEK-1 | MEK1 | MP2K1_HUMAN | Mitogen-activated protein kinase 1 (MEK1) | PRKMK1 | VHL-MAP2K1/MAP2K2 |
|---|
| Type: | Other Protein Type |
|---|
| Mol. Mass.: | 43439.03 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Full-length human MEK-1 was generated by PCR and purified as a fusion protein from Escherichia coli lysates. |
|---|
| Residue: | 393 |
|---|
| Sequence: | MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
|
|
|
|---|
| BDBM29896 |
|---|
| n/a |
|---|
| Name | BDBM29896 |
|---|
| Synonyms: | 1,7-naphthyridine-3-carbonitrile, 1 | CHEMBL197538 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H20ClFN6O |
|---|
| Mol. Mass. | 426.875 |
|---|
| SMILES | Fc1ccc(Nc2c(cnc3cnc(NCCN4CCOCC4)cc23)C#N)cc1Cl |
|---|
| Structure | 
|
|---|
Search and Browse
