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TargetCarbonic anhydrase 12
LigandBDBM50174034
Substrate/Competitorn/a
Meas. Tech.ChEMBL_320720 (CHEMBL881706)
Ki 3.3±n/a nM
Citation Ozensoy, OPuccetti, LFasolis, GArslan, OScozzafava, ASupuran, CT Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett15:4862-6 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Carbonic anhydrase 12
Name:Carbonic anhydrase 12
Synonyms:CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3
Type:Enzyme
Mol. Mass.:39456.00
Organism:Homo sapiens (Human)
Description:Catalytic domain of human cloned isozyme was used in the assay
Residue:354
Sequence:
MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50174034
n/a
NameBDBM50174034
Synonyms:5-(4-Bromo-cyclohexa-2,4-dienesulfonylamino)-[1,3,4]thiadiazole-2-sulfonic acid amide | CHEMBL194634
TypeSmall organic molecule
Emp. Form.C8H7BrN4O4S3
Mol. Mass.399.265
SMILESNS(=O)(=O)c1nnc(NS(=O)(=O)c2ccc(Br)cc2)s1
Structure
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