| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 12 |
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| Ligand | BDBM16647 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_320720 (CHEMBL881706) |
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| Ki | 138±n/a nM |
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| Citation |  Ozensoy, O; Puccetti, L; Fasolis, G; Arslan, O; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozymes IX and XII with a library of aromatic and heteroaromatic sulfonamides. Bioorg Med Chem Lett15:4862-6 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 12 |
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| Name: | Carbonic anhydrase 12 |
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| Synonyms: | CA-XII | CA12 | CAH12_HUMAN | Carbonate dehydratase XII | Carbonic anhydrase | Carbonic anhydrase 12 (CA XII) | Carbonic anhydrase XII | Carbonic anhydrase XII (CA XII) | Carbonic anhydrase XII (CAXII) | Tumor antigen HOM-RCC-3.1.3 |
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| Type: | Enzyme |
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| Mol. Mass.: | 39456.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Catalytic domain of human cloned isozyme was used in the assay |
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| Residue: | 354 |
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| Sequence: | MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYPSCGGLLQSPIDL
HSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQGLQSRYSATQLHL
HWGNPNDPHGSEHTVSGQHFAAELHIVHYNSDLYPDASTASNKSEGLAVLAVLIEMGSFN
PSYDKIFSHLQHVKYKGQEAFVPGFNIEELLPERTAEYYRYRGSLTTPPCNPTVLWTVFR
NPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTSFSQVQVCTAAGL
SLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
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| BDBM16647 |
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| n/a |
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| Name | BDBM16647 |
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| Synonyms: | 2-methyl-N-(4-sulfamoylphenyl)propanamide | 4-Isobutanamido-benzenesulfonamide | CHEMBL23417 | aromatic sulfonamide compound 12 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H14N2O3S |
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| Mol. Mass. | 242.295 |
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| SMILES | CC(C)C(=O)Nc1ccc(cc1)S(N)(=O)=O |
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| Structure | 
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