Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetPhenylethanolamine N-methyltransferase
LigandBDBM13023
Substrate/Competitorn/a
Meas. Tech.ChEMBL_326878 (CHEMBL862979)
Ki 52±n/a nM
Citation Grunewald, GLLu, JCriscione, KROkoro, CO Inhibitors of phenylethanolamine N-methyltransferase devoid of alpha2-adrenoceptor affinity. Bioorg Med Chem Lett15:5319-23 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Phenylethanolamine N-methyltransferase
Name:Phenylethanolamine N-methyltransferase
Synonyms:Noradrenaline N-methyltransferase | PENT | PNMT | PNMT_HUMAN | PNMTase | Phenylethanolamine N-Methyltransferase (PNMT)
Type:Enzyme
Mol. Mass.:30852.66
Organism:Homo sapiens (Human)
Description:n/a
Residue:282
Sequence:
MSGADRSPNAGAAPDSAPGQAAVASAYQRFEPRAYLRNNYAPPRGDLCNPNGVGPWKLRC
LAQTFATGEVSGRTLIDIGSGPTVYQLLSACSHFEDITMTDFLEVNRQELGRWLQEEPGA
FNWSMYSQHACLIEGKGECWQDKERQLRARVKRVLPIDVHQPQPLGAGSPAPLPADALVS
AFCLEAVSPDLASFQRALDHITTLLRPGGHLLLIGALEESWYLAGEARLTVVPVSEEEVR
EALVRSGYKVRDLRTYIMPAHLQTGVDDVKGVFFAWAQKVGL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM13023
n/a
NameBDBM13023
Synonyms:3-(hydroxymethyl)-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide | 7-sulfonamide-THIQ 13 | CHEMBL41647
TypeSmall organic molecule
Emp. Form.C10H14N2O3S
Mol. Mass.242.295
SMILESNS(=O)(=O)c1ccc2CC(CO)NCc2c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: