Reaction Details |
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Target | RNA-directed RNA polymerase |
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Ligand | BDBM50115579 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_321538 (CHEMBL880598) |
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pH | 7.5±n/a |
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IC50 | 5600±n/a nM |
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Comments | extracted |
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Citation | Di Santo, R; Fermeglia, M; Ferrone, M; Paneni, MS; Costi, R; Artico, M; Roux, A; Gabriele, M; Tardif, KD; Siddiqui, A; Pricl, S Simple but highly effective three-dimensional chemical-feature-based pharmacophore model for diketo acid derivatives as hepatitis C virus RNA-dependent RNA polymerase inhibitors. J Med Chem48:6304-14 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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RNA-directed RNA polymerase |
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Name: | RNA-directed RNA polymerase |
Synonyms: | Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein |
Type: | Protein |
Mol. Mass.: | 25173.95 |
Organism: | Hepatitis C virus |
Description: | Q8JXU8 |
Residue: | 229 |
Sequence: | RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
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BDBM50115579 |
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n/a |
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Name | BDBM50115579 |
Synonyms: | (Z)-2-hydroxy-4-oxo-4-phenyl-but-2-enoic acid | 2-Hydroxy-4-oxo-4-phenyl-but-2-enoic acid | 2-Hydroxy-4-oxo-4-phenyl-but-2-enoic acid (0.25H2O) | CHEMBL16326 | CHEMBL19332 | CHEMBL467389 | Sacchettini_CTRL |
Type | Small organic molecule |
Emp. Form. | C10H8O4 |
Mol. Mass. | 192.1681 |
SMILES | OC(=O)C(=O)CC(=O)c1ccccc1 |
Structure |
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