Reaction Details |
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Target | Aurora kinase A |
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Ligand | BDBM50174695 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_326666 (CHEMBL868729) |
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IC50 | 1900±n/a nM |
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Citation | Pan, W; Liu, H; Xu, YJ; Chen, X; Kim, KH; Milligan, DL; Columbus, J; Hadari, YR; Kussie, P; Wong, WC; Labelle, M Pyrimido-oxazepine as a versatile template for the development of inhibitors of specific kinases. Bioorg Med Chem Lett15:5474-7 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Aurora kinase A |
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Name: | Aurora kinase A |
Synonyms: | AIK | AIRK1 | ARK1 | AURA | AURKA | AURKA_HUMAN | AYK1 | Aurora 2 | Aurora kinase A (AURA) | Aurora kinase A (AURKA) | Aurora kinase A (Aurora A) | Aurora kinase A (Aurora-2) | Aurora-related kinase 1 | Aurora/IPL1-related kinase 1 | BTAK | Breast tumor-amplified kinase | Breast-tumor-amplified kinase | IAK1 | STK15 | STK6 | Serine/threonine kinase 15 | Serine/threonine-protein kinase 6 | Serine/threonine-protein kinase aurora A | aurora-2 | hARK1 |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 45830.98 |
Organism: | Homo sapiens (Human) |
Description: | O14965 |
Residue: | 403 |
Sequence: | MDRSKENCISGPVKATAPVGGPKRVLVTQQFPCQNPLPVNSGQAQRVLCPSNSSQRVPLQ
AQKLVSSHKPVQNQKQKQLQATSVPHPVSRPLNNTQKSKQPLPSAPENNPEEELASKQKN
EESKKRQWALEDFEIGRPLGKGKFGNVYLAREKQSKFILALKVLFKAQLEKAGVEHQLRR
EVEIQSHLRHPNILRLYGYFHDATRVYLILEYAPLGTVYRELQKLSKFDEQRTATYITEL
ANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSVHAPSSRRTTLCGTLDYLPPEM
IEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTYQETYKRISRVEFTFPDFVTEGARDLI
SRLLKHNPSQRPMLREVLEHPWITANSSKPSNCQNKESASKQS
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BDBM50174695 |
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n/a |
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Name | BDBM50174695 |
Synonyms: | CHEMBL199476 | N-[5-(10,11-dihydro-5-oxa-2,4,11-triaza-dibenzo[a,d]cyclohepten-1-ylamino)-pyrimidin-2-yl]-benzamide |
Type | Small organic molecule |
Emp. Form. | C22H17N7O2 |
Mol. Mass. | 411.4161 |
SMILES | O=C(Nc1ncc(Nc2ncnc3Oc4ccccc4CNc23)cn1)c1ccccc1 |
Structure |
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