| Reaction Details |
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 | Report a problem with these data |
| Target | Enoyl-acyl-carrier protein reductase |
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| Ligand | BDBM50174768 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_326719 (CHEMBL858717) |
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| IC50 | 220±n/a nM |
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| Citation |  Freundlich, JS; Anderson, JW; Sarantakis, D; Shieh, HM; Yu, M; Valderramos, JC; Lucumi, E; Kuo, M; Jacobs, WR; Fidock, DA; Schiehser, GA; Jacobus, DP; Sacchettini, JC Synthesis, biological activity, and X-ray crystal structural analysis of diaryl ether inhibitors of malarial enoyl acyl carrier protein reductase. Part 1: 4'-substituted triclosan derivatives. Bioorg Med Chem Lett15:5247-52 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Enoyl-acyl-carrier protein reductase |
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| Name: | Enoyl-acyl-carrier protein reductase |
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| Synonyms: | n/a |
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| Type: | PROTEIN |
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| Mol. Mass.: | 49770.86 |
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| Organism: | Plasmodium falciparum |
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| Description: | ChEMBL_795989 |
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| Residue: | 432 |
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| Sequence: | MNKISQRLLFLFLHFYTTVCFIQNNTQKTFHNVLQNEQIRGKEKAFYRKEKRENIFIGNK
MKHVHNMNNTHNNNHYMEKEEQDASNINKIKEENKNEDICFIAGIGDTNGYGWGIAKELS
KRNVKIIFGIWPPVYNIFMKNYKNGKFDNDMIIDKDKKMNILDMLPFDASFDTANDIDEE
TKNNKRYNMLQNYPIEDVANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSK
SSYSLISLCKYFVNIMKPQSSIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLAYHLG
RNYNIRINTISAGPLKSRAATAINKLNNTYENNTNQNKNRNSHDVHNIMNNSGEKEEKKN
SASQNYTFIDYAIEYSEKYAPLRQKLLSTDIGSVASFLLSRESRAITGQTIYVDNGLNIM
FLPDDIYRNENE
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| BDBM50174768 |
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| n/a |
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| Name | BDBM50174768 |
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| Synonyms: | 5‐chloro‐2‐(2‐chloro‐4‐hydroxyphenoxy)phenol (5) | 5-chloro-2-(2-chloro-4-hydroxyphenoxy)phenol | CHEMBL200379 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H8Cl2O3 |
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| Mol. Mass. | 271.096 |
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| SMILES | Oc1ccc(Oc2ccc(Cl)cc2O)c(Cl)c1 |
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| Structure | 
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