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TargetCoagulation factor X
LigandBDBM50175078
Substrate/Competitorn/a
Meas. Tech.ChEMBL_326962 (CHEMBL853297)
IC50 10±n/a nM
Citation Shi, YZhang, JStein, PDShi, MO'Connor, SPBisaha, SNLi, CAtwal, KSBisacchi, GSSitkoff, DPudzianowski, ATLiu, ECHartl, KSSeiler, SMYoussef, SSteinbacher, TESchumacher, WARendina, ARBozarth, JMPeterson, TLZhang, GZahler, R Ketene aminal-based lactam derivatives as a novel class of orally active FXa inhibitors. Bioorg Med Chem Lett15:5453-8 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Coagulation factor X
Name:Coagulation factor X
Synonyms:Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:Enzyme
Mol. Mass.:54726.60
Organism:Homo sapiens (Human)
Description:n/a
Residue:488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEE
TCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKN
CELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERR
KRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQE
CKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGE
AVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGI
VSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSG
GPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPE
VITSSPLK
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  Blast E-value cutoff:
BDBM50175078
n/a
NameBDBM50175078
Synonyms:(S,Z)-3-(1-(2-methylbenzofuran-5-ylamino)-3-oxo-3-(thiazol-2-yl)prop-1-enylamino)-1-(2-oxo-2-(pyrrolidin-1-yl)ethyl)azepan-2-one | CHEMBL197542
TypeSmall organic molecule
Emp. Form.C27H31N5O4S
Mol. Mass.521.631
SMILESCc1cc2cc(ccc2o1)N=C(CC(=O)c1nccs1)N[C@H]1CCCCN(CC(=O)N2CCCC2)C1=O |w:10.11|
Structure
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