Reaction Details |
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Target | P2Y purinoceptor 12 |
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Ligand | BDBM50118223 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_326588 (CHEMBL863371) |
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Kd | 4.57±n/a nM |
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Citation | El-Tayeb, A; Griessmeier, KJ; Müller, CE Synthesis and preliminary evaluation of [3H]PSB-0413, a selective antagonist radioligand for platelet P2Y12 receptors. Bioorg Med Chem Lett15:5450-2 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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P2Y purinoceptor 12 |
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Name: | P2Y purinoceptor 12 |
Synonyms: | ADP-glucose receptor | ADPG-R | HORK3 | P2RY12 | P2T(AC) | P2Y purinoceptor 12 | P2Y(AC) | P2Y(ADP) | P2Y(cyc) | P2Y12 | P2Y12 platelet ADP receptor | P2Y12_HUMAN | Purinergic receptor P2Y12 | SP1999 |
Type: | Enzyme |
Mol. Mass.: | 39458.48 |
Organism: | Homo sapiens (Human) |
Description: | Q9H244 |
Residue: | 342 |
Sequence: | MQAVDNLTSAPGNTSLCTRDYKITQVLFPLLYTVLFFVGLITNGLAMRIFFQIRSKSNFI
IFLKNTVISDLLMILTFPFKILSDAKLGTGPLRTFVCQVTSVIFYFTMYISISFLGLITI
DRYQKTTRPFKTSNPKNLLGAKILSVVIWAFMFLLSLPNMILTNRQPRDKNVKKCSFLKS
EFGLVWHEIVNYICQVIFWINFLIVIVCYTLITKELYRSYVRTRGVGKVPRKKVNVKVFI
IIAVFFICFVPFHFARIPYTLSQTRDVFDCTAENTLFYVKESTLWLTSLNACLDPFIYFF
LCKSFRNSLISMLKCPNSATSLSQDNRKKEQDGGDPNEETPM
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BDBM50118223 |
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n/a |
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Name | BDBM50118223 |
Synonyms: | AR-C67085 | Adenosine triphosphate derivative | CHEMBL336292 | CHEMBL369928 |
Type | Small organic molecule |
Emp. Form. | C14H22Cl2N5O12P3S |
Mol. Mass. | 648.243 |
SMILES | CCCSc1nc(N)c2ncn([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)C(Cl)(Cl)P(O)(O)=O)[C@@H](O)[C@H]3O)c2n1 |
Structure |
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