Reaction Details |
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Target | Tyrosine-protein kinase Fyn |
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Ligand | BDBM50175199 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_328616 (CHEMBL864488) |
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IC50 | >50000±n/a nM |
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Citation | Burchat, A; Borhani, DW; Calderwood, DJ; Hirst, GC; Li, B; Stachlewitz, RF Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection. Bioorg Med Chem Lett16:118-22 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Tyrosine-protein kinase Fyn |
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Name: | Tyrosine-protein kinase Fyn |
Synonyms: | FYN | FYN_HUMAN | Proto-oncogene Syn | Proto-oncogene c-Fyn | SLK | SRC | Src-like kinase | p59-Fyn |
Type: | Enzyme |
Mol. Mass.: | 60762.21 |
Organism: | Homo sapiens (Human) |
Description: | P06241 |
Residue: | 537 |
Sequence: | MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG
LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW
EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET
TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC
RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT
LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR
ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY
TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE
RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL
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BDBM50175199 |
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n/a |
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Name | BDBM50175199 |
Synonyms: | CHEMBL371459 | N-(4-(1-(1-(1-acetylpiperidin-4-yl)piperidin-4-yl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenyl)-2-fluoro-4-(trifluoromethyl)benzamide |
Type | Small organic molecule |
Emp. Form. | C32H34F4N8O3 |
Mol. Mass. | 654.6578 |
SMILES | COc1cc(ccc1NC(=O)c1ccc(cc1F)C(F)(F)F)-c1nn(C2CCN(CC2)C2CCN(CC2)C(C)=O)c2ncnc(N)c12 |
Structure |
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