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TargetCathepsin L1
LigandBDBM50175213
Substrate/Competitorn/a
Meas. Tech.ChEMBL_326940
Ki 6400±n/a nM
Citation Martina EStiefl NDegel BSchulz FBreuning ASchiller MVicik RBaumann KZiebuhr JSchirmeister T Screening of electrophilic compounds yields an aziridinyl peptide as new active-site directed SARS-CoV main protease inhibitor. Bioorg Med Chem Lett 15:5365-9 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cathepsin L1
Name:Cathepsin (L and K)
Synonyms:Cathepsin (L and K) | Cathepsin L | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:Enzyme
Mol. Mass.:37557.19
Organism:Homo sapiens (Human)
Description:Purchased from Calbiochem (San Diego, CA).
Residue:333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50175213
n/a
NameBDBM50175213
Synonyms:(2S,3S)-dibenzyl 1-((S)-2-(tert-butoxycarbonyl)-2-(piperidin-1-yl)acetyl)aziridine-2,3-dicarboxylate | CHEMBL198858
TypeSmall organic molecule
Emp. Form.C30H37N3O7
Mol. Mass.551.6307
SMILESCC(C)(C)OC(=O)N[C@@H](N1CCCCC1)C(=O)N1[C@@H]([C@H]1C(=O)OCc1ccccc1)C(=O)OCc1ccccc1
Structure
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