| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Extracellular calcium-sensing receptor |
|---|
| Ligand | BDBM50175364 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_326644 (CHEMBL863377) |
|---|
| IC50 | 2670±n/a nM |
|---|
| Citation |  Gavai, AV; Vaz, RJ; Mikkilineni, AB; Roberge, JY; Liu, Y; Lawrence, RM; Corte, JR; Yang, W; Bednarz, M; Dickson, JK; Ma, Z; Seethala, R; Feyen, JH Discovery of novel 1-arylmethyl pyrrolidin-2-yl ethanol amines as calcium-sensing receptor antagonists. Bioorg Med Chem Lett15:5478-82 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Extracellular calcium-sensing receptor |
|---|
| Name: | Extracellular calcium-sensing receptor |
|---|
| Synonyms: | CASR | CASR_HUMAN | CaR | Calcium sensing receptor | Calcium-sensing receptor (CaSR) | Extracellular calcium-sensing receptor | GPRC2A | PCAR1 | Parathyroid Cell calcium-sensing receptor | Parathyroid cell calcium-sensing receptor 1 | Synonyms=GPRC2A | hCasR |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 120663.13 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P41180 |
|---|
| Residue: | 1078 |
|---|
| Sequence: | MAFYSCCWVLLALTWHTSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVEC
IRYNFRGFRWLQAMIFAIEEINSSPALLPNLTLGYRIFDTCNTVSKALEATLSFVAQNKI
DSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQF
KSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFS
ELISQYSDEEEIQHVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGKIWLASEAWA
SSSLIAMPQYFHVVGGTIGFALKAGQIPGFREFLKKVHPRKSVHNGFAKEFWEETFNCHL
QEGAKGPLPVDTFLRGHEESGDRFSNSSTAFRPLCTGDENISSVETPYIDYTHLRISYNV
YLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFD
ECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFS
NCSRDCLAGTRKGIIEGEPTCCFECVECPDGEYSDETDASACNKCPDDFWSNENHTSCIA
KEIEFLSWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLC
CFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWG
LNLQFLLVFLCTFMQIVICVIWLYTAPPSSYRNQELEDEIIFITCHEGSLMALGFLIGYT
CLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIA
ILAASFGLLACIFFNKIYIILFKPSRNTIEEVRCSTAAHAFKVAARATLRRSNVSRKRSS
SLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQP
RCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTRHEPLLPLQCGE
TDLDLTVQETGLQGPVGGDQRPEVEDPEELSPALVVSSSQSFVISGGGSTVTENVVNS
|
|
|
|---|
| BDBM50175364 |
|---|
| n/a |
|---|
| Name | BDBM50175364 |
|---|
| Synonyms: | 3-(((R)-2-((R)-1-hydroxy-2-(1-(4-methoxyphenyl)-2-methylpropan-2-ylamino)ethyl)pyrrolidin-1-yl)methyl)benzonitrile | CHEMBL370671 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H33N3O2 |
|---|
| Mol. Mass. | 407.5484 |
|---|
| SMILES | COc1ccc(CC(C)(C)NC[C@@H](O)[C@H]2CCCN2Cc2cccc(c2)C#N)cc1 |
|---|
| Structure | 
|
|---|
Search and Browse
