| Reaction Details |
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 | Report a problem with these data |
| Target | Estrogen receptor beta |
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| Ligand | BDBM50175415 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_326623 (CHEMBL868723) |
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| IC50 | 15.1±n/a nM |
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| Citation |  Chesworth, R; Wessel, MD; Heyden, L; Mangano, FM; Zawistoski, M; Gegnas, L; Galluzzo, D; Lefker, B; Cameron, KO; Tickner, J; Lu, B; Castleberry, TA; Petersen, DN; Brault, A; Perry, P; Ng, O; Owen, TA; Pan, L; Ke, HZ; Brown, TA; Thompson, DD; DaSilva-Jardine, P Estrogen receptor beta selective ligands: discovery and SAR of novel heterocyclic ligands. Bioorg Med Chem Lett15:5562-6 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Estrogen receptor beta |
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| Name: | Estrogen receptor beta |
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| Synonyms: | ER-beta | ESR2 | ESR2_HUMAN | ESTRB | Estradiol receptor beta (ERβ) | Estrogen receptor | Estrogen receptor (ER beta) | Estrogen receptor beta | Estrogen receptor beta (ER beta) | Estrogen receptor beta (ER) | NR3A2 | Nuclear receptor subfamily 3 group A member 2 | estrogen beta |
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| Type: | Protein |
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| Mol. Mass.: | 59238.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q92731 |
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| Residue: | 530 |
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| Sequence: | MDIKNSPSSLNSPSSYNCSQSILPLEHGSIYIPSSYVDSHHEYPAMTFYSPAVMNYSIPS
NVTNLEGGPGRQTTSPNVLWPTPGHLSPLVVHRQLSHLYAEPQKSPWCEARSLEHTLPVN
RETLKRKVSGNRCASPVTGPGSKRDAHFCAVCSDYASGYHYGVWSCEGCKAFFKRSIQGH
NDYICPATNQCTIDKNRRKSCQACRLRKCYEVGMVKCGSRRERCGYRLVRRQRSADEQLH
CAGKAKRSGGHAPRVRELLLDALSPEQLVLTLLEAEPPHVLISRPSAPFTEASMMMSLTK
LADKELVHMISWAKKIPGFVELSLFDQVRLLESCWMEVLMMGLMWRSIDHPGKLIFAPDL
VLDRDEGKCVEGILEIFDMLLATTSRFRELKLQHKEYLCVKAMILLNSSMYPLVTATQDA
DSSRKLAHLLNAVTDALVWVIAKSGISSQQQSMRLANLLMLLSHVRHASNKGMEHLLNMK
CKNVVPVYDLLLEMLNAHVLRGCKSSITGSECSPAEDSKSKEGSQNPQSQ
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| BDBM50175415 |
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| n/a |
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| Name | BDBM50175415 |
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| Synonyms: | 4-(5-phenyl-2-(trifluoromethyl)-1H-imidazol-4-yl)phenol | CHEMBL200799 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H11F3N2O |
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| Mol. Mass. | 304.2665 |
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| SMILES | Oc1ccc(cc1)-c1[nH]c(nc1-c1ccccc1)C(F)(F)F |
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| Structure | 
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