| Reaction Details |
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 | Report a problem with these data |
| Target | Interstitial collagenase |
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| Ligand | BDBM50175534 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_321355 (CHEMBL881499) |
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| IC50 | 1.3±n/a nM |
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| Citation |  Alberts, IL; Todorov, NP; Dean, PM Receptor flexibility in de novo ligand design and docking. J Med Chem48:6585-96 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interstitial collagenase |
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| Name: | Interstitial collagenase |
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| Synonyms: | CLG | Fibroblast collagenase | MMP1 | MMP1_HUMAN | Matrix metalloproteinase-1 | Matrix metalloproteinase-1 (MMP-1) |
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| Type: | Enzyme |
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| Mol. Mass.: | 54010.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P03956 |
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| Residue: | 469 |
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| Sequence: | MHSFPPLLLLLFWGVVSHSFPATLETQEQDVDLVQKYLEKYYNLKNDGRQVEKRRNSGPV
VEKLKQMQEFFGLKVTGKPDAETLKVMKQPRCGVPDVAQFVLTEGNPRWEQTHLTYRIEN
YTPDLPRADVDHAIEKAFQLWSNVTPLTFTKVSEGQADIMISFVRGDHRDNSPFDGPGGN
LAHAFQPGPGIGGDAHFDEDERWTNNFREYNLHRVAAHELGHSLGLSHSTDIGALMYPSY
TFSGDVQLAQDDIDGIQAIYGRSQNPVQPIGPQTPKACDSKLTFDAITTIRGEVMFFKDR
FYMRTNPFYPEVELNFISVFWPQLPNGLEAAYEFADRDEVRFFKGNKYWAVQGQNVLHGY
PKDIYSSFGFPRTVKHIDAALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFP
GIGHKVDAVFMKDGFFYFFHGTRQYKFDPKTKRILTLQKANSWFNCRKN
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| BDBM50175534 |
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| n/a |
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| Name | BDBM50175534 |
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| Synonyms: | CHEMBL370842 | N-Hydroxy-3-(7-oxo-7,8-dihydro-6H-quinolizine-4-sulfonyl)-propionamide |
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| Type | Small organic molecule |
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| Emp. Form. | C12H14N2O5S |
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| Mol. Mass. | 298.315 |
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| SMILES | ONC(=O)CCS(=O)(=O)C1=CC=CC2=CCC(=O)CN12 |c:11,t:9,13| |
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| Structure | 
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