Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50175719 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_328881 (CHEMBL860461) |
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EC50 | 14±n/a nM |
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Citation | Trabanco, AA; Pullan, S; Alonso, JM; Alvarez, RM; Andrés, JI; Boeckx, I; Fernández, J; Gómez, A; Iturrino, L; Janssens, FE; Leenaerts, JE; De Lucas, AI; Matesanz, E; Meert, T; Steckler, T 4-Phenyl-4-[1H-imidazol-2-yl]-piperidine derivatives, a novel class of selective delta-opioid agonists. Bioorg Med Chem Lett16:146-9 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50175719 |
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n/a |
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Name | BDBM50175719 |
Synonyms: | 2-(4-(1-benzyl-1H-imidazol-2-yl)-4-phenylpiperidin-1-yl)pyrimidine | CHEMBL202238 |
Type | Small organic molecule |
Emp. Form. | C25H25N5 |
Mol. Mass. | 395.4995 |
SMILES | C(c1ccccc1)n1ccnc1C1(CCN(CC1)c1ncccn1)c1ccccc1 |
Structure |
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