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TargetMitogen-activated protein kinase 14
LigandBDBM50175752
Substrate/Competitorn/a
Meas. Tech.ChEMBL_328205 (CHEMBL863917)
IC50 1.6±n/a nM
Citation Bao, JHunt, JAMiao, SRupprecht, KMStelmach, JELiu, LRuzek, RDSinclair, PJPivnichny, JVHop, CEKumar, SZaller, DMShoop, WLO'neill, EAO'keefe, SJThompson, CMCubbon, RMWang, RZhang, WXThompson, JEDoherty, JB p38 MAP kinase inhibitors: metabolically stabilized piperidine-substituted quinolinones and naphthyridinones. Bioorg Med Chem Lett16:64-8 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 14
Name:Mitogen-activated protein kinase 14
Synonyms:CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:Serine/threonine-protein kinase
Mol. Mass.:41286.76
Organism:Homo sapiens (Human)
Description:Q16539
Residue:360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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BDBM50175752
n/a
NameBDBM50175752
Synonyms:7-(1-tert-butylpiperidin-4-yloxy)-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)quinolin-2(1H)-one | CHEMBL199707
TypeSmall organic molecule
Emp. Form.C30H29Cl3N2O2
Mol. Mass.555.922
SMILESCC(C)(C)N1CCC(CC1)Oc1cc(-c2ccccc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1 |(6.9,-20.6,;5.57,-19.84,;4.8,-21.17,;6.35,-18.51,;4.24,-19.07,;2.9,-19.84,;1.57,-19.07,;1.56,-17.53,;2.9,-16.75,;4.24,-17.53,;.23,-16.76,;-1.1,-17.54,;-1.1,-19.09,;-2.43,-19.86,;-2.43,-21.4,;-3.77,-22.16,;-3.77,-23.7,;-2.44,-24.47,;-1.1,-23.7,;-1.1,-22.16,;.23,-21.39,;-3.77,-19.09,;-5.1,-19.87,;-6.44,-19.09,;-6.44,-17.55,;-7.77,-16.77,;-5.1,-16.78,;-5.1,-15.24,;-6.43,-14.48,;-7.76,-15.25,;-6.43,-12.94,;-5.09,-12.17,;-3.76,-12.94,;-3.76,-14.48,;-2.43,-15.25,;-3.77,-17.54,;-2.44,-16.77,)|
Structure
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