Reaction Details | |||
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Target | Mitogen-activated protein kinase 14 | ||
Ligand | BDBM50175752 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_328205 (CHEMBL863917) | ||
IC50 | 1.6±n/a nM | ||
Citation | Bao, J; Hunt, JA; Miao, S; Rupprecht, KM; Stelmach, JE; Liu, L; Ruzek, RD; Sinclair, PJ; Pivnichny, JV; Hop, CE; Kumar, S; Zaller, DM; Shoop, WL; O'neill, EA; O'keefe, SJ; Thompson, CM; Cubbon, RM; Wang, R; Zhang, WX; Thompson, JE; Doherty, JB p38 MAP kinase inhibitors: metabolically stabilized piperidine-substituted quinolinones and naphthyridinones. Bioorg Med Chem Lett16:64-8 (2005) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Mitogen-activated protein kinase 14 | |||
Name: | Mitogen-activated protein kinase 14 | ||
Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta | ||
Type: | Serine/threonine-protein kinase | ||
Mol. Mass.: | 41286.76 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q16539 | ||
Residue: | 360 | ||
Sequence: |
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BDBM50175752 | |||
n/a | |||
Name | BDBM50175752 | ||
Synonyms: | 7-(1-tert-butylpiperidin-4-yloxy)-5-(2-chlorophenyl)-1-(2,6-dichlorophenyl)quinolin-2(1H)-one | CHEMBL199707 | ||
Type | Small organic molecule | ||
Emp. Form. | C30H29Cl3N2O2 | ||
Mol. Mass. | 555.922 | ||
SMILES | CC(C)(C)N1CCC(CC1)Oc1cc(-c2ccccc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1 |(6.9,-20.6,;5.57,-19.84,;4.8,-21.17,;6.35,-18.51,;4.24,-19.07,;2.9,-19.84,;1.57,-19.07,;1.56,-17.53,;2.9,-16.75,;4.24,-17.53,;.23,-16.76,;-1.1,-17.54,;-1.1,-19.09,;-2.43,-19.86,;-2.43,-21.4,;-3.77,-22.16,;-3.77,-23.7,;-2.44,-24.47,;-1.1,-23.7,;-1.1,-22.16,;.23,-21.39,;-3.77,-19.09,;-5.1,-19.87,;-6.44,-19.09,;-6.44,-17.55,;-7.77,-16.77,;-5.1,-16.78,;-5.1,-15.24,;-6.43,-14.48,;-7.76,-15.25,;-6.43,-12.94,;-5.09,-12.17,;-3.76,-12.94,;-3.76,-14.48,;-2.43,-15.25,;-3.77,-17.54,;-2.44,-16.77,)| | ||
Structure |