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TargetMitogen-activated protein kinase 14
LigandBDBM50175756
Substrate/Competitorn/a
Meas. Tech.ChEMBL_328206 (CHEMBL863945)
IC50 2.59±n/a nM
Citation Bao, JHunt, JAMiao, SRupprecht, KMStelmach, JELiu, LRuzek, RDSinclair, PJPivnichny, JVHop, CEKumar, SZaller, DMShoop, WLO'neill, EAO'keefe, SJThompson, CMCubbon, RMWang, RZhang, WXThompson, JEDoherty, JB p38 MAP kinase inhibitors: metabolically stabilized piperidine-substituted quinolinones and naphthyridinones. Bioorg Med Chem Lett16:64-8 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 14
Name:Mitogen-activated protein kinase 14
Synonyms:CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:Serine/threonine-protein kinase
Mol. Mass.:41286.76
Organism:Homo sapiens (Human)
Description:Q16539
Residue:360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQ
SIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQ
KLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMT
GYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVG
TPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAA
QALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
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BDBM50175756
n/a
NameBDBM50175756
Synonyms:CHEMBL199632 | methyl 2-(4-(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-2-oxo-1,2-dihydroquinolin-7-yl)piperidin-1-yl)-2-methylpropanoate
TypeSmall organic molecule
Emp. Form.C31H28Cl3FN2O3
Mol. Mass.601.923
SMILESCOC(=O)C(C)(C)N1CCC(CC1)c1cc(-c2ccc(F)cc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1 |(20.15,-17.01,;20.14,-15.47,;18.8,-14.71,;18.79,-13.17,;17.48,-15.49,;18.25,-16.82,;16.7,-14.16,;16.14,-16.26,;16.14,-17.8,;14.81,-18.57,;13.47,-17.81,;13.47,-16.26,;14.81,-15.49,;12.14,-18.58,;12.15,-20.13,;10.81,-20.9,;10.81,-22.44,;9.48,-23.21,;9.47,-24.74,;10.81,-25.52,;10.81,-27.06,;12.15,-24.74,;12.14,-23.2,;13.47,-22.43,;9.48,-20.13,;8.15,-20.91,;6.81,-20.13,;6.81,-18.59,;5.47,-17.82,;8.14,-17.82,;8.15,-16.29,;6.82,-15.52,;5.49,-16.29,;6.81,-13.98,;8.15,-13.21,;9.49,-13.98,;9.48,-15.52,;10.82,-16.29,;9.47,-18.59,;10.81,-17.82,)|
Structure
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