Reaction Details | |||
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Target | Mitogen-activated protein kinase 14 | ||
Ligand | BDBM50175756 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_328206 (CHEMBL863945) | ||
IC50 | 2.59±n/a nM | ||
Citation | Bao, J; Hunt, JA; Miao, S; Rupprecht, KM; Stelmach, JE; Liu, L; Ruzek, RD; Sinclair, PJ; Pivnichny, JV; Hop, CE; Kumar, S; Zaller, DM; Shoop, WL; O'neill, EA; O'keefe, SJ; Thompson, CM; Cubbon, RM; Wang, R; Zhang, WX; Thompson, JE; Doherty, JB p38 MAP kinase inhibitors: metabolically stabilized piperidine-substituted quinolinones and naphthyridinones. Bioorg Med Chem Lett16:64-8 (2005) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Mitogen-activated protein kinase 14 | |||
Name: | Mitogen-activated protein kinase 14 | ||
Synonyms: | CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta | ||
Type: | Serine/threonine-protein kinase | ||
Mol. Mass.: | 41286.76 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q16539 | ||
Residue: | 360 | ||
Sequence: |
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BDBM50175756 | |||
n/a | |||
Name | BDBM50175756 | ||
Synonyms: | CHEMBL199632 | methyl 2-(4-(5-(2-chloro-4-fluorophenyl)-1-(2,6-dichlorophenyl)-2-oxo-1,2-dihydroquinolin-7-yl)piperidin-1-yl)-2-methylpropanoate | ||
Type | Small organic molecule | ||
Emp. Form. | C31H28Cl3FN2O3 | ||
Mol. Mass. | 601.923 | ||
SMILES | COC(=O)C(C)(C)N1CCC(CC1)c1cc(-c2ccc(F)cc2Cl)c2ccc(=O)n(-c3c(Cl)cccc3Cl)c2c1 |(20.15,-17.01,;20.14,-15.47,;18.8,-14.71,;18.79,-13.17,;17.48,-15.49,;18.25,-16.82,;16.7,-14.16,;16.14,-16.26,;16.14,-17.8,;14.81,-18.57,;13.47,-17.81,;13.47,-16.26,;14.81,-15.49,;12.14,-18.58,;12.15,-20.13,;10.81,-20.9,;10.81,-22.44,;9.48,-23.21,;9.47,-24.74,;10.81,-25.52,;10.81,-27.06,;12.15,-24.74,;12.14,-23.2,;13.47,-22.43,;9.48,-20.13,;8.15,-20.91,;6.81,-20.13,;6.81,-18.59,;5.47,-17.82,;8.14,-17.82,;8.15,-16.29,;6.82,-15.52,;5.49,-16.29,;6.81,-13.98,;8.15,-13.21,;9.49,-13.98,;9.48,-15.52,;10.82,-16.29,;9.47,-18.59,;10.81,-17.82,)| | ||
Structure |