Reaction Details |
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Target | Heparanase |
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Ligand | BDBM50175811 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_327891 (CHEMBL868733) |
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IC50 | 230±n/a nM |
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Citation | Xu, YJ; Miao, HQ; Pan, W; Navarro, EC; Tonra, JR; Mitelman, S; Camara, MM; Deevi, DS; Kiselyov, AS; Kussie, P; Wong, WC; Liu, H N-(4-{[4-(1H-Benzoimidazol-2-yl)-arylamino]-methyl}-phenyl)-benzamide derivatives as small molecule heparanase inhibitors. Bioorg Med Chem Lett16:404-8 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Heparanase |
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Name: | Heparanase |
Synonyms: | Endo-glucoronidase | HEP | HPA | HPA1 | HPR1 | HPSE | HPSE1 | HPSE_HUMAN | HSE1 | Heparanase 50 kDa subunit | Heparanase 8 kDa subunit | Heparanase-1 |
Type: | PROTEIN |
Mol. Mass.: | 61167.67 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_327900 |
Residue: | 543 |
Sequence: | MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVT
IDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQS
QVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKFKNSTYSRSSVDVLYTFANCS
GLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNEPNSFLKKADIFINGS
QLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYL
NGRTATKEDFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDTFA
AGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLFKKLVGTKVLM
ASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKYLL
RPLGPHGLLSKSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVA
ACI
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BDBM50175811 |
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n/a |
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Name | BDBM50175811 |
Synonyms: | CHEMBL200215 | N-(4-{[4-(1H-benzoimidazol-2-yl)phenylamino]methyl}phenyl)-3-bromo-4-methoxy-benzamide |
Type | Small organic molecule |
Emp. Form. | C28H23BrN4O2 |
Mol. Mass. | 527.412 |
SMILES | COc1ccc(cc1Br)C(=O)Nc1ccc(CNc2ccc(cc2)-c2nc3ccccc3[nH]2)cc1 |
Structure |
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