Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetHeparanase
LigandBDBM50175931
Substrate/Competitorn/a
Meas. Tech.ChEMBL_327900 (CHEMBL869912)
IC50 150±n/a nM
Citation Pan, WMiao, HQXu, YJNavarro, ECTonra, JRCorcoran, ELahiji, AKussie, PKiselyov, ASWong, WCLiu, H 1-[4-(1H-Benzoimidazol-2-yl)-phenyl]-3-[4-(1H-benzoimidazol-2-yl)-phenyl]-urea derivatives as small molecule heparanase inhibitors. Bioorg Med Chem Lett16:409-12 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Heparanase
Name:Heparanase
Synonyms:Endo-glucoronidase | HEP | HPA | HPA1 | HPR1 | HPSE | HPSE1 | HPSE_HUMAN | HSE1 | Heparanase 50 kDa subunit | Heparanase 8 kDa subunit | Heparanase-1
Type:PROTEIN
Mol. Mass.:61167.67
Organism:Homo sapiens (Human)
Description:ChEMBL_327900
Residue:543
Sequence:
MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVT
IDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQS
QVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKFKNSTYSRSSVDVLYTFANCS
GLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNEPNSFLKKADIFINGS
QLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYL
NGRTATKEDFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDTFA
AGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLFKKLVGTKVLM
ASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKYLL
RPLGPHGLLSKSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVA
ACI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50175931
n/a
NameBDBM50175931
Synonyms:1-(4-(1H-benzo[d]imidazol-2-yl)phenyl)-3-(4-(7-methyl-1H-benzo[d]imidazol-2-yl)phenyl)urea | CHEMBL199610
TypeSmall organic molecule
Emp. Form.C28H22N6O
Mol. Mass.458.5139
SMILESCc1cccc2[nH]c(nc12)-c1ccc(NC(=O)Nc2ccc(cc2)-c2nc3ccccc3[nH]2)cc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: