Reaction Details |
| Report a problem with these data |
Target | Sodium-dependent serotonin transporter |
---|
Ligand | BDBM50029150 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_320901 (CHEMBL872400) |
---|
Ki | 2±n/a nM |
---|
Citation | Smid, P; Coolen, HK; Keizer, HG; van Hes, R; de Moes, JP; den Hartog, AP; Stork, B; Plekkenpol, RH; Niemann, LC; Stroomer, CN; Tulp, MT; van Stuivenberg, HH; McCreary, AC; Hesselink, MB; Herremans, AH; Kruse, CG Synthesis, structure-activity relationships, and biological properties of 1-heteroaryl-4-[omega-(1H-indol-3-yl)alkyl]piperazines, novel potential antipsychotics combining potent dopamine D2 receptor antagonism with potent serotonin reuptake inhibition. J Med Chem48:6855-69 (2005) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Sodium-dependent serotonin transporter |
---|
Name: | Sodium-dependent serotonin transporter |
Synonyms: | 5-HT Transporter | 5-HTT | 5HT transporter | 5HTT | Anandamid membrane transporter, AMT | Anandamide membrane transporter, AMT | Monoamine transporters; Norepinephrine & serotonin | SC6A4_RAT | Slc6a4 | Sodium-dependent serotonin transporter | Sodium-dependent serotonin transporter (SERT) | imipramine receptor |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 70168.43 |
Organism: | Rattus norvegicus (rat) |
Description: | P31652 |
Residue: | 630 |
Sequence: | METTPLNSQKVLSECKDREDCQENGVLQKGVPTTADRAEPSQISNGYSAVPSTSAGDEAS
HSIPAATTTLVAEIRQGERETWGKKMDFLLSVIGYAVDLGNIWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTII
AWALYYLISSLTDRLPWTSCTNSWNTGNCTNYFAQDNITWTLHSTSPAEEFYLRHVLQIH
QSKGLQDLGTISWQLTLCIVLIFTVIYFSIWKGVKTSGKVVWVTATFPYIVLSVLLVRGA
TLPGAWRGVVFYLKPNWQKLLETGVWVDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHIWAKRREWFVLIVVITCVLGSLLT
LTSGGAYVVTLLEEYATGPAVLTVALIEAVAVSWFYGITQFCSDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPHWSIVLGYCIGMSSVICIPTYIIYRLIST
PGTLKERIIKSITPETPTEIPCGDIRMNAV
|
|
|
BDBM50029150 |
---|
n/a |
---|
Name | BDBM50029150 |
Synonyms: | 3-(2-Piperidin-4-yl-ethyl)-1H-indole | CHEMBL276520 | Indalpine |
Type | Small organic molecule |
Emp. Form. | C15H20N2 |
Mol. Mass. | 228.3327 |
SMILES | C(Cc1c[nH]c2ccccc12)C1CCNCC1 |
Structure |
|