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TargetIntegrase
LigandBDBM50176118
Substrate/Competitorn/a
Meas. Tech.ChEMBL_321433 (CHEMBL880241)
IC50 220±n/a nM
Citation Barreca, MLFerro, SRao, ADe Luca, LZappalà, MMonforte, AMDebyser, ZWitvrouw, MChimirri, A Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors. J Med Chem48:7084-8 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Integrase
Name:Integrase
Synonyms:Human immunodeficiency virus type 1 integrase
Type:PROTEIN
Mol. Mass.:32231.48
Organism:Human immunodeficiency virus 1
Description:ChEMBL_90865
Residue:288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
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  Blast E-value cutoff:
BDBM50176118
n/a
NameBDBM50176118
Synonyms:(Z)-4-(1-Benzyl-5-chloro-1H-indol-3-yl)-2-hydroxy-4-oxo-but-2-enoic acid ethyl ester | CHEMBL197001
TypeSmall organic molecule
Emp. Form.C21H18ClNO4
Mol. Mass.383.825
SMILESCCOC(=O)C(=O)CC(=O)c1cn(Cc2ccccc2)c2ccc(Cl)cc12
Structure
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