| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50176127 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_321394 (CHEMBL880629) |
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| IC50 | 70±n/a nM |
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| Citation |  Barreca, ML; Ferro, S; Rao, A; De Luca, L; Zappalà, M; Monforte, AM; Debyser, Z; Witvrouw, M; Chimirri, A Pharmacophore-based design of HIV-1 integrase strand-transfer inhibitors. J Med Chem48:7084-8 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | Human immunodeficiency virus type 1 integrase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32231.48 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_90865 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
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| BDBM50176127 |
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| n/a |
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| Name | BDBM50176127 |
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| Synonyms: | (Z)-4-[5-Chloro-1-(4-fluoro-benzyl)-1H-indol-3-yl]-2-hydroxy-4-oxo-but-2-enoic acid ethyl ester | CHEMBL365604 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H17ClFNO4 |
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| Mol. Mass. | 401.815 |
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| SMILES | CCOC(=O)C(=O)CC(=O)c1cn(Cc2ccc(F)cc2)c2ccc(Cl)cc12 |
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| Structure | 
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