Reaction Details |
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Target | Prothrombin |
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Ligand | BDBM50176241 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_327712 (CHEMBL860417) |
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Ki | 1±n/a nM |
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Citation | Isaacs, RC; Solinsky, MG; Cutrona, KJ; Newton, CL; Naylor-Olsen, AM; Krueger, JA; Lewis, SD; Lucas, BJ Structure-based design of novel groups for use in the P1 position of thrombin inhibitor scaffolds. Part 1: Weakly basic azoles. Bioorg Med Chem Lett16:338-42 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Prothrombin |
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Name: | Prothrombin |
Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain |
Type: | Protein |
Mol. Mass.: | 70029.57 |
Organism: | Homo sapiens (Human) |
Description: | P00734 |
Residue: | 622 |
Sequence: | MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
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BDBM50176241 |
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n/a |
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Name | BDBM50176241 |
Synonyms: | (S)-1-((R)-2-amino-3,3-diphenylpropanoyl)-N-((E)-3-(4-methyl-1H-imidazol-5-yl)allyl)pyrrolidine-2-carboxamide | CHEMBL200153 |
Type | Small organic molecule |
Emp. Form. | C27H31N5O2 |
Mol. Mass. | 457.5673 |
SMILES | Cc1nc[nH]c1C=CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](N)C(c1ccccc1)c1ccccc1 |w:7.8| |
Structure |
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