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TargetHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
LigandBDBM50176377
Substrate/Competitorn/a
Meas. Tech.ChEMBL_334413 (CHEMBL864323)
IC50>16000±n/a nM
Citation Chambers, RJ; Abrams, K; Castleberry, TA; Cheng, JB; Fisher, DA; Kamath, AV; Marfat, A; Nettleton, DO; Pillar, JD; Salter, ED; Sheils, AL; Shirley, JT; Turner, CR; Umland, JP; Lam, KT A new chemical tool for exploring the role of the PDE4D isozyme in leukocyte function. Bioorg Med Chem Lett16:718-21 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Name:High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A
Synonyms:3',5'-cyclic phosphodiesterase | PDE9A | PDE9A_HUMAN | Phosphodiesterase 9A | Phosphodiesterase 9A (PDE9) | Phosphodiesterase 9A (PDE9A)
Type:Protein
Mol. Mass.:68488.40
Organism:Homo sapiens (Human)
Description:O76083
Residue:593
Sequence:
MGSGSSSYRPKAIYLDIDGRIQKVIFSKYCNSSDIMDLFCIATGLPRNTTISLLTTDDAM
VSIDPTMPANSERTPYKVRPVAIKQLSAGVEDKRTTSRGQSAERPLRDRRVVGLEQPRRE
GAFESGQVEPRPREPQGCYQEGQRIPPEREELIQSVLAQVAEQFSRAFKINELKAEVANH
LAVLEKRVELEGLKVVEIEKCKSDIKKMREELAARSSRTNCPCKYSFLDNHKKLTPRRDV
PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLF
CVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYN
NTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLI
LATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCL
LEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIML
QPLWESRDRYEELKRIDDAMKELQKKTDSLTSGATEKSRERSRDVKNSEGDCA
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BDBM50176377
n/a
NameBDBM50176377
Synonyms:(R)-2-(4-fluorophenoxy)-N-(1-(thiophen-2-yl)ethyl)nicotinamide | CHEMBL204449
TypeSmall organic molecule
Emp. Form.C18H15FN2O2S
Mol. Mass.342.387
SMILESC[C@@H](NC(=O)c1cccnc1Oc1ccc(F)cc1)c1cccs1
Structure
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