| Reaction Details |
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 | Report a problem with these data |
| Target | Cannabinoid receptor 1 |
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| Ligand | BDBM50176403 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_333260 (CHEMBL859079) |
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| Ki | 0.6±n/a nM |
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| Citation |  Carpino, PA; Griffith, DA; Sakya, S; Dow, RL; Black, SC; Hadcock, JR; Iredale, PA; Scott, DO; Fichtner, MW; Rose, CR; Day, R; Dibrino, J; Butler, M; Debartolo, DB; Dutcher, D; Gautreau, D; Lizano, JS; O'connor, RE; Sands, MA; Kelly-Sullivan, D; Ward, KM New bicyclic cannabinoid receptor-1 (CB1-R) antagonists. Bioorg Med Chem Lett16:731-6 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cannabinoid receptor 1 |
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| Name: | Cannabinoid receptor 1 |
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| Synonyms: | CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 52868.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P21554 |
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| Residue: | 472 |
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| Sequence: | MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
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| BDBM50176403 |
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| n/a |
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| Name | BDBM50176403 |
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| Synonyms: | 2-(2-chlorophenyl)-3-(4-chlorophenyl)-6-(2,2-difluoroethyl)-2H-pyrazolo[4,3-d]pyrimidin-7(6H)-one | CHEMBL201565 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H12Cl2F2N4O |
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| Mol. Mass. | 421.228 |
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| SMILES | FC(F)Cn1cnc2c(-c3ccc(Cl)cc3)n(nc2c1=O)-c1ccccc1Cl |
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| Structure | 
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