| Reaction Details |
|---|
 | Report a problem with these data |
| Target | RNA-directed RNA polymerase |
|---|
| Ligand | BDBM50176482 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_329786 (CHEMBL864623) |
|---|
| IC50 | 4460±n/a nM |
|---|
| Citation |  Gopalsamy, A; Aplasca, A; Ciszewski, G; Park, K; Ellingboe, JW; Orlowski, M; Feld, B; Howe, AY Design and synthesis of 3,4-dihydro-1H-[1]-benzothieno[2,3-c]pyran and 3,4-dihydro-1H-pyrano[3,4-b]benzofuran derivatives as non-nucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase. Bioorg Med Chem Lett16:457-60 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| RNA-directed RNA polymerase |
|---|
| Name: | RNA-directed RNA polymerase |
|---|
| Synonyms: | Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 25173.95 |
|---|
| Organism: | Hepatitis C virus |
|---|
| Description: | Q8JXU8 |
|---|
| Residue: | 229 |
|---|
| Sequence: | RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
|
|
|
|---|
| BDBM50176482 |
|---|
| n/a |
|---|
| Name | BDBM50176482 |
|---|
| Synonyms: | (1-butyl-5,8-dichloro-3,4-dihydro-1H-benzo[4,5]furo[2,3-c]pyran-1-yl)-acetic acid | CHEMBL373183 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H18Cl2O4 |
|---|
| Mol. Mass. | 357.228 |
|---|
| SMILES | CCCCC1(CC(O)=O)OCCc2c1oc1c(Cl)ccc(Cl)c21 |
|---|
| Structure | 
|
|---|
Search and Browse
