Reaction Details |
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Target | RNA-directed RNA polymerase |
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Ligand | BDBM50176475 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_329791 (CHEMBL853261) |
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EC50 | 3200±n/a nM |
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Citation | Gopalsamy, A; Aplasca, A; Ciszewski, G; Park, K; Ellingboe, JW; Orlowski, M; Feld, B; Howe, AY Design and synthesis of 3,4-dihydro-1H-[1]-benzothieno[2,3-c]pyran and 3,4-dihydro-1H-pyrano[3,4-b]benzofuran derivatives as non-nucleoside inhibitors of HCV NS5B RNA dependent RNA polymerase. Bioorg Med Chem Lett16:457-60 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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RNA-directed RNA polymerase |
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Name: | RNA-directed RNA polymerase |
Synonyms: | Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein |
Type: | Protein |
Mol. Mass.: | 25173.95 |
Organism: | Hepatitis C virus |
Description: | Q8JXU8 |
Residue: | 229 |
Sequence: | RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLT
CYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPP
QPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIM
FAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
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BDBM50176475 |
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n/a |
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Name | BDBM50176475 |
Synonyms: | ((R)-5-cyano-6-fluoro-8-methyl-1-propyl-3,4-dihydro-1H-benzo[4,5]thieno[2,3-c]pyran-1-yl)-acetic acid | CHEMBL380997 |
Type | Small organic molecule |
Emp. Form. | C18H18FNO3S |
Mol. Mass. | 347.404 |
SMILES | CCC[C@]1(CC(O)=O)OCCc2c1sc1c(C)cc(F)c(C#N)c21 |
Structure |
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