Reaction Details |
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Target | D(3) dopamine receptor |
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Ligand | BDBM50177356 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_331690 (CHEMBL862890) |
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Ki | 1.3±n/a nM |
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Citation | Geneste, H; Backfisch, G; Braje, W; Delzer, J; Haupt, A; Hutchins, CW; King, LL; Kling, A; Teschendorf, HJ; Unger, L; Wernet, W Synthesis and SAR of highly potent and selective dopamine D(3)-receptor antagonists: 1H-pyrimidin-2-one derivatives. Bioorg Med Chem Lett16:490-4 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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D(3) dopamine receptor |
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Name: | D(3) dopamine receptor |
Synonyms: | DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3 |
Type: | n/a |
Mol. Mass.: | 44243.43 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 400 |
Sequence: | MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK
LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
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BDBM50177356 |
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n/a |
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Name | BDBM50177356 |
Synonyms: | 1-(4-(4-(2-tert-butyl-6-(trifluoromethyl)pyrimidin-4-yl)piperazin-1-yl)butyl)-4-hydroxy-5-methylpyrimidin-2(1H)-one | A-690344 | CHEMBL201115 |
Type | Small organic molecule |
Emp. Form. | C22H31F3N6O2 |
Mol. Mass. | 468.5157 |
SMILES | Cc1cn(CCCCN2CCN(CC2)c2cc(nc(n2)C(C)(C)C)C(F)(F)F)c(=O)[nH]c1=O |
Structure |
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