| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50177556 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_334179 (CHEMBL866473) |
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| Ki | 9±n/a nM |
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| Citation |  Berlin, M; Ting, PC; Vaccaro, WD; Aslanian, R; McCormick, KD; Lee, JF; Albanese, MM; Mutahi, MW; Piwinski, JJ; Shih, NY; Duguma, L; Solomon, DM; Zhou, W; Sher, R; Favreau, L; Bryant, M; Korfmacher, WA; Nardo, C; West, RE; Anthes, JC; Williams, SM; Wu, RL; Susan She, H; Rivelli, MA; Corboz, MR; Hey, JA Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl]piperidine series of histamine H3 receptor antagonists. Bioorg Med Chem Lett16:989-94 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | HISTAMINE H3 | HRH3 | HRH3_CAVPO | Histamine H3 receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 48753.61 |
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| Organism: | GUINEA PIG |
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| Description: | HISTAMINE H3 HRH3 GUINEA PIG::Q9JI35 |
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| Residue: | 445 |
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| Sequence: | MERAPPDGLMNASGALAGEAAAAAGGARTFSAAWTAVLAALMALLIVATVLGNALVMLAF
VADSSLRTQNNFFLLNLAISDFLVGVFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCT
SSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMVLVWVLAFLLYGPAILSWEYLSG
GSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGARE
AGPDPLPEAQSSPPQPPPGCWGCWPKGQGESMPLHRYGVGEAGPGAEAGEAALGGGSGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHSSLEHCWK
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| BDBM50177556 |
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| n/a |
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| Name | BDBM50177556 |
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| Synonyms: | 5-(4-(3-(4-((1H-imidazol-4-yl)methyl)piperidin-1-yl)propoxy)phenyl)pyrimidine | CHEMBL204639 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H27N5O |
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| Mol. Mass. | 377.4827 |
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| SMILES | C(COc1ccc(cc1)-c1cncnc1)CN1CCC(Cc2cnc[nH]2)CC1 |
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| Structure | 
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