| Reaction Details |
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 | Report a problem with these data |
| Target | Melanocortin receptor 4 |
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| Ligand | BDBM50177559 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_349444 (CHEMBL865696) |
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| Ki | 107±n/a nM |
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| Citation |  Shi, Q; Ornstein, PL; Briner, K; Richardson, TI; Arnold, MB; Backer, RT; Buckmaster, JL; Canada, EJ; Doecke, CW; Hertel, LW; Honigschmidt, N; Hsiung, HM; Husain, S; Kuklish, SL; Martinelli, MJ; Mullaney, JT; O'Brien, TP; Reinhard, MR; Rothhaar, R; Shah, J; Wu, Z; Xie, C; Zgombick, JM; Fisher, MJ Synthesis and structure-activity relationships of novel dipeptides and reduced dipeptides as ligands for melanocortin subtype-4 receptor. Bioorg Med Chem Lett16:2341-6 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Melanocortin receptor 4 |
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| Name: | Melanocortin receptor 4 |
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| Synonyms: | MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R) |
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| Type: | Enzyme |
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| Mol. Mass.: | 36949.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32245 |
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| Residue: | 332 |
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| Sequence: | MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLL
ENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVN
IDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVS
GILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGAN
MKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPL
IYALRSQELRKTFKEIICCYPLGGLCDLSSRY
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| BDBM50177559 |
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| n/a |
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| Name | BDBM50177559 |
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| Synonyms: | CHEMBL379352 | N-((R)-3-(4-chlorophenyl)-1-(4-(1-(2-chlorophenyl)-2-(diethylamino)ethyl)piperazin-1-yl)-1-oxopropan-2-yl)-2-(isoindolin-1-yl)acetamide |
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| Type | Small organic molecule |
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| Emp. Form. | C35H43Cl2N5O2 |
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| Mol. Mass. | 636.654 |
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| SMILES | CCN(CC)CC(N1CCN(CC1)C(=O)[C@@H](Cc1ccc(Cl)cc1)NC(=O)CC1NCc2ccccc12)c1ccccc1Cl |
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| Structure | 
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