| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium-dependent serotonin transporter |
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| Ligand | BDBM50130169 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_349601 (CHEMBL866278) |
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| Ki | 0.58±n/a nM |
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| Citation |  Takeuchi, K; Kohn, TJ; Honigschmidt, NA; Rocco, VP; Spinazze, PG; Hemrick-Luecke, SK; Thompson, LK; Evans, DC; Rasmussen, K; Koger, D; Lodge, D; Martin, LJ; Shaw, J; Threlkeld, PG; Wong, DT Advances toward new antidepressants beyond SSRIs: 1-aryloxy-3-piperidinylpropan-2-ols with dual 5-HT1A receptor antagonism/SSRI activities. Part 5. Bioorg Med Chem Lett16:2347-51 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium-dependent serotonin transporter |
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| Name: | Sodium-dependent serotonin transporter |
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| Synonyms: | 5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4 |
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| Type: | Multi-pass membrane protein |
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| Mol. Mass.: | 70322.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P31645 |
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| Residue: | 630 |
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| Sequence: | METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTR
HSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLP
YTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIM
AWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIH
RSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGA
TLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQD
ALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPAS
TFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVT
LTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRIC
WVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIIT
PGTFKERIIKSITPETPTEIPCGDIRLNAV
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| BDBM50130169 |
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| n/a |
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| Name | BDBM50130169 |
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| Synonyms: | (S)-1-(1H-indol-4-yloxy)-3-((2S,4R)-4-(5-chlorobenzo[b]thiophen-2-yl)-2-methylpiperidin-1-yl)propan-2-ol | (S)-1-[(4S,6R)-4-(5-Chloro-benzo[b]thiophen-2-yl)-2-methyl-piperidin-1-yl]-3-(1H-indol-4-yloxy)-propan-2-ol | CHEMBL79151 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27ClN2O2S |
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| Mol. Mass. | 455.012 |
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| SMILES | C[C@H]1C[C@@H](CCN1C[C@H](O)COc1cccc2[nH]ccc12)c1cc2cc(Cl)ccc2s1 |
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| Structure | 
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