Reaction Details |
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Target | Cathepsin K |
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Ligand | BDBM50410605 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_325792 (CHEMBL862698) |
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Ki | 230±n/a nM |
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Citation | Palmer, JT; Bryant, C; Wang, DX; Davis, DE; Setti, EL; Rydzewski, RM; Venkatraman, S; Tian, ZQ; Burrill, LC; Mendonca, RV; Springman, E; McCarter, J; Chung, T; Cheung, H; Janc, JW; McGrath, M; Somoza, JR; Enriquez, P; Yu, ZW; Strickley, RM; Liu, L; Venuti, MC; Percival, MD; Falgueyret, JP; Prasit, P; Oballa, R; Riendeau, D; Young, RN; Wesolowski, G; Rodan, SB; Johnson, C; Kimmel, DB; Rodan, G Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K. J Med Chem48:7520-34 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cathepsin K |
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Name: | Cathepsin K |
Synonyms: | CATK_RABIT | CTSK |
Type: | Enzyme |
Mol. Mass.: | 36879.51 |
Organism: | Oryctolagus cuniculus (rabbit) |
Description: | n/a |
Residue: | 329 |
Sequence: | MWGLKVLLLPVVSFALHPEEILDTQWELWKKTYSKQYNSKVDEISRRLIWEKNLKHISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPPSRSHSNDTLYIPDWEGRTPDSID
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENYGCGGG
YMTNAFQYVQRNRGIDSEDAYPYVGQDESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDENCSSDNVNHAVLAVGYGIQKGNKHWIIKNSWGE
SWGNKGYILMARNKNNACGIANLASFPKM
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BDBM50410605 |
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n/a |
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Name | BDBM50410605 |
Synonyms: | CHEMBL200529 |
Type | Small organic molecule |
Emp. Form. | C17H23N3O3 |
Mol. Mass. | 317.3828 |
SMILES | CC(C)(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NCC#N |
Structure |
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