| Reaction Details |
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 | Report a problem with these data |
| Target | Dynamin-1 |
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| Ligand | BDBM4363 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_326472 (CHEMBL864467) |
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| IC50 | 70000±n/a nM |
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| Citation |  Hill, T; Odell, LR; Edwards, JK; Graham, ME; McGeachie, AB; Rusak, J; Quan, A; Abagyan, R; Scott, JL; Robinson, PJ; McCluskey, A Small molecule inhibitors of dynamin I GTPase activity: development of dimeric tyrphostins. J Med Chem48:7781-8 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dynamin-1 |
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| Name: | Dynamin-1 |
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| Synonyms: | DNM | DNM1 | DYN1_HUMAN | Dynamin-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 97411.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1458576 |
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| Residue: | 864 |
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| Sequence: | MGNRGMEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRG
SGIVTRRPLVLQLVNATTEYAEFLHCKGKKFTDFEEVRLEIEAETDRVTGTNKGISPVPI
NLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQIRDMLMQFVTKENCLILAVSPANSD
LANSDALKVAKEVDPQGQRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQK
DIDGKKDITAALAAERKFFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKL
QSQLLSIEKEVEEYKNFRPDDPARKTKALLQMVQQFAVDFEKRIEGSGDQIDTYELSGGA
RINRIFHERFPFELVKMEFDEKELRREISYAIKNIHGIRTGLFTPDMAFETIVKKQVKKI
REPCLKCVDMVISELISTVRQCTKKLQQYPRLREEMERIVTTHIREREGRTKEQVMLLID
IELAYMNTNHEDFIGFANAQQRSNQMNKKKTSGNQDEILVIRKGWLTINNIGIMKGGSKE
YWFVLTAENLSWYKDDEEKEKKYMLSVDNLKLRDVEKGFMSSKHIFALFNTEQRNVYKDY
RQLELACETQEEVDSWKASFLRAGVYPERVGDKEKASETEENGSDSFMHSMDPQLERQVE
TIRNLVDSYMAIVNKTVRDLMPKTIMHLMINNTKEFIFSELLANLYSCGDQNTLMEESAE
QAQRRDEMLRMYHALKEALSIIGDINTTTVSTPMPPPVDDSWLQVQSVPAGRRSPTSSPT
PQRRAPAVPPARPGSRGPAPGPPPAGSALGGAPPVPSRPGASPDPFGPPPQVPSRPNRAP
PGVPSRSGQASPSRPESPRPPFDL
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| BDBM4363 |
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| n/a |
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| Name | BDBM4363 |
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| Synonyms: | (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethioamide | AG 213 | CHEMBL77030 | RG-50864 | T7540 (Tyrphostin 47) | Tyrphostin A47 | alpha-Cyano-(3,4-dihydroxy)thiocinnamide | benzylidenemalononitrile (BMN) deriv. 47 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H8N2O2S |
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| Mol. Mass. | 220.248 |
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| SMILES | NC(=S)C(=C\c1ccc(O)c(O)c1)\C#N |
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| Structure | 
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