| Reaction Details |
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 | Report a problem with these data |
| Target | NAD-dependent histone deacetylase SIR2 |
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| Ligand | BDBM50177983 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_326721 (CHEMBL859799) |
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| IC50 | 62000±n/a nM |
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| Citation |  Mai, A; Massa, S; Lavu, S; Pezzi, R; Simeoni, S; Ragno, R; Mariotti, FR; Chiani, F; Camilloni, G; Sinclair, DA Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. J Med Chem48:7789-95 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| NAD-dependent histone deacetylase SIR2 |
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| Name: | NAD-dependent histone deacetylase SIR2 |
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| Synonyms: | MAR1 | SIR2 | SIR2_YEAST |
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| Type: | PROTEIN |
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| Mol. Mass.: | 63277.80 |
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| Organism: | Saccharomyces cerevisiae |
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| Description: | ChEMBL_942450 |
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| Residue: | 562 |
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| Sequence: | MTIPHMKYAVSKTSENKVSNTVSPTQDKDAIRKQPDDIINNDEPSHKKIKVAQPDSLRET
NTTDPLGHTKAALGEVASMELKPTNDMDPLAVSAASVVSMSNDVLKPETPKGPIIISKNP
SNGIFYGPSFTKRESLNARMFLKYYGAHKFLDTYLPEDLNSLYIYYLIKLLGFEVKDQAL
IGTINSIVHINSQERVQDLGSAISVTNVEDPLAKKQTVRLIKDLQRAINKVLCTRLRLSN
FFTIDHFIQKLHTARKILVLTGAGVSTSLGIPDFRSSEGFYSKIKHLGLDDPQDVFNYNI
FMHDPSVFYNIANMVLPPEKIYSPLHSFIKMLQMKGKLLRNYTQNIDNLESYAGISTDKL
VQCHGSFATATCVTCHWNLPGERIFNKIRNLELPLCPYCYKKRREYFPEGYNNKVGVAAS
QGSMSERPPYILNSYGVLKPDITFFGEALPNKFHKSIREDILECDLLICIGTSLKVAPVS
EIVNMVPSHVPQVLINRDPVKHAEFDLSLLGYCDDIAAMVAQKCGWTIPHKKWNDLKNKN
FKCQEKDKGVYVVTSDEHPKTL
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| BDBM50177983 |
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| n/a |
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| Name | BDBM50177983 |
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| Synonyms: | (R)-sirtinol | CHEMBL198582 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H22N2O2 |
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| Mol. Mass. | 394.4651 |
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| SMILES | C[C@@H](NC(=O)c1ccccc1\N=C\c1c(O)ccc2ccccc12)c1ccccc1 |
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| Structure | 
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