Reaction Details |
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Target | NAD-dependent histone deacetylase SIR2 |
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Ligand | BDBM50156760 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_326721 (CHEMBL859799) |
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IC50 | 48000±n/a nM |
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Citation | Mai, A; Massa, S; Lavu, S; Pezzi, R; Simeoni, S; Ragno, R; Mariotti, FR; Chiani, F; Camilloni, G; Sinclair, DA Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors. J Med Chem48:7789-95 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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NAD-dependent histone deacetylase SIR2 |
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Name: | NAD-dependent histone deacetylase SIR2 |
Synonyms: | MAR1 | SIR2 | SIR2_YEAST |
Type: | PROTEIN |
Mol. Mass.: | 63277.80 |
Organism: | Saccharomyces cerevisiae |
Description: | ChEMBL_942450 |
Residue: | 562 |
Sequence: | MTIPHMKYAVSKTSENKVSNTVSPTQDKDAIRKQPDDIINNDEPSHKKIKVAQPDSLRET
NTTDPLGHTKAALGEVASMELKPTNDMDPLAVSAASVVSMSNDVLKPETPKGPIIISKNP
SNGIFYGPSFTKRESLNARMFLKYYGAHKFLDTYLPEDLNSLYIYYLIKLLGFEVKDQAL
IGTINSIVHINSQERVQDLGSAISVTNVEDPLAKKQTVRLIKDLQRAINKVLCTRLRLSN
FFTIDHFIQKLHTARKILVLTGAGVSTSLGIPDFRSSEGFYSKIKHLGLDDPQDVFNYNI
FMHDPSVFYNIANMVLPPEKIYSPLHSFIKMLQMKGKLLRNYTQNIDNLESYAGISTDKL
VQCHGSFATATCVTCHWNLPGERIFNKIRNLELPLCPYCYKKRREYFPEGYNNKVGVAAS
QGSMSERPPYILNSYGVLKPDITFFGEALPNKFHKSIREDILECDLLICIGTSLKVAPVS
EIVNMVPSHVPQVLINRDPVKHAEFDLSLLGYCDDIAAMVAQKCGWTIPHKKWNDLKNKN
FKCQEKDKGVYVVTSDEHPKTL
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BDBM50156760 |
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n/a |
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Name | BDBM50156760 |
Synonyms: | (E)-2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N-(1-phenylethyl)benzamide | 2-((2-hydroxynaphthalen-1-yl)methyleneamino)-N-(1-phenylethyl)benzamide | 2-{[(1-(2-hydroxy-naphthalen-1-yl)meth-(E)-ylidene]amino}-N-(1-phenylethyl)-benzamide | 2-{[1-(2-hydroxynaphthalen-1-yl)meth-(E)-ylene]amino}-N-(1-phenylethyl)benzamide | CHEMBL380797 | Sirtinol |
Type | Small organic molecule |
Emp. Form. | C26H22N2O2 |
Mol. Mass. | 394.4651 |
SMILES | CC(NC(=O)c1ccccc1\N=C\c1c(O)ccc2ccccc12)c1ccccc1 |
Structure |
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