Ki Summary

Reaction Details

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Target

Adenosine kinase

Ligand

BDBM50090895

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_325687 (CHEMBL864546)

IC50

1.5±n/a nM

Citation

Bookser, BC; Ugarkar, BG; Matelich, MC; Lemus, RH; Allan, M; Tsuchiya, M; Nakane, M; Nagahisa, A; Wiesner, JB; Erion, MD Adenosine kinase inhibitors. 6. Synthesis, water solubility, and antinociceptive activity of 5-phenyl-7-(5-deoxy-beta-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidines substituted at C4 with glycinamides and related compounds. J Med Chem48:7808-20 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Adenosine kinase

Name:

Adenosine kinase

Synonyms:

ADK | ADK_HUMAN

Type:

PROTEIN

Mol. Mass.:

40545.97

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1467841

Residue:

362

Sequence:

MAAAEEEPKPKKLKVEAPQALRENILFGMGNPLLDISAVVDKDFLDKYSLKPNDQILAED
KHKELFDELVKKFKVEYHAGGSTQNSIKVAQWMIQQPHKAATFFGCIGIDKFGEILKRKA
AEAHVDAHYYEQNEQPTGTCAACITGDNRSLIANLAAANCYKKEKHLDLEKNWMLVEKAR
VCYIAGFFLTVSPESVLKVAHHASENNRIFTLNLSAPFISQFYKESLMKVMPYVDILFGN
ETEAATFAREQGFETKDIKEIAKKTQALPKMNSKRQRIVIFTQGRDDTIMATESEVTAFA
VLDQDQKEIIDTNGAGDAFVGGFLSQLVSDKPLTECIRAGHYAASIIIRRTGCTFPEKPD
FH

BDBM50090895

n/a

Name

BDBM50090895

Synonyms:

(2R,3R,4S,5R)-2-[4-(4-Fluoro-phenylamino)-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl]-5-methyl-tetrahydro-furan-3,4-diol | (2S,3S,4R,5S)-2-[4-(4-Fluoro-phenylamino)-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl]-5-methyl-tetrahydro-furan-3,4-diol | 2-[4-(4-Fluoro-phenylamino)-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl]-5-methyl-tetrahydro-furan-3,4-diol | 4-(4-fluorophenylamino)-5-phenyl-7-(5-deoxy-beta-D-ribofuranosyl)-pyrrolo[2,3-d]pyrimidine | CHEMBL66277

Type

Small organic molecule

Emp. Form.

C23H21FN4O3

Mol. Mass.

420.4362

SMILES

C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cc(-c2ccccc2)c2c(Nc3ccc(F)cc3)ncnc12

Structure