Reaction Details |
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Target | Substance-P receptor |
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Ligand | BDBM50178565 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_337893 (CHEMBL868375) |
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Ki | 0.58±n/a nM |
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Citation | Hoffmann, T; Bös, M; Stadler, H; Schnider, P; Hunkeler, W; Godel, T; Galley, G; Ballard, TM; Higgins, GA; Poli, SM; Sleight, AJ Design and synthesis of a novel, achiral class of highly potent and selective, orally active neurokinin-1 receptor antagonists. Bioorg Med Chem Lett16:1362-5 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Substance-P receptor |
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Name: | Substance-P receptor |
Synonyms: | NK-1 receptor | NK-1R | NK1 Receptor | NK1R | NK1R_HUMAN | Neurokinin 1 receptor | Neurokinin-1 (NK-1) | Neuromedin-1 receptor (NK-1R) | SPR | TAC1R | TACR1 | Tachykinin receptor 1 | Tachykinin receptor 1 (NK1) | tachykinin |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 46254.43 |
Organism: | Homo sapiens (Human) |
Description: | P25103 |
Residue: | 407 |
Sequence: | MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
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BDBM50178565 |
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n/a |
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Name | BDBM50178565 |
Synonyms: | CHEMBL206488 | N-(3,5-bis(trifluoromethyl)benzyl)-N-methyl-6-(4-methylpiperazin-1-yl)-4-o-tolylnicotinamide |
Type | Small organic molecule |
Emp. Form. | C28H28F6N4O |
Mol. Mass. | 550.5385 |
SMILES | CN(Cc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(=O)c1cnc(cc1-c1ccccc1C)N1CCN(C)CC1 |
Structure |
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