| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Trypanothione reductase |
|---|
| Ligand | BDBM50178810 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_326414 (CHEMBL864478) |
|---|
| IC50 | 30500±n/a nM |
|---|
| Citation |  Parveen, S; Khan, MO; Austin, SE; Croft, SL; Yardley, V; Rock, P; Douglas, KT Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class of trypanothione reductase inhibitor, and of N-acyl derivatives of 2-amino-4-chlorophenyl phenyl sulfide. J Med Chem48:8087-97 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Trypanothione reductase |
|---|
| Name: | Trypanothione reductase |
|---|
| Synonyms: | N(1),N(8)-bis(glutathionyl)spermidine reductase | TPR | TR | TYTR_TRYCR |
|---|
| Type: | Homodimer; oxidoreductase |
|---|
| Mol. Mass.: | 53868.26 |
|---|
| Organism: | Trypanosoma cruzi |
|---|
| Description: | n/a |
|---|
| Residue: | 492 |
|---|
| Sequence: | MMSKIFDLVVIGAGSGGLEAAWNAATLYKKRVAVIDVQMVHGPPFFSALGGTCVNVGCVP
KKLMVTGAQYMEHLRESAGFGWEFDRTTLRAEWKKLIAVKDEAVLNINKSYEEMFRDTEG
LEFFLGWGSLESKNVVNVRESADPASAVKERLETENILLASGSWPHMPNIPGIEHCISSN
EAFYLPEPPRRVLTVGGGFISVEFAGIFNAYKPKDGQVTLCYRGEMILRGFDHTLREELT
KQLTANGIQILTKENPAKVELNADGSKSVTFESGKKMDFDLVMMAIGRSPRTKDLQLQNA
GVMIKNGGVQVDEYSRTNVSNIYAIGDVTNRVMLTPVAINEAAALVDTVFGTNPRKTDHT
RVASAVFSIPPIGTCGLIEEVASKRYEVVAVYLSSFTPLMHNISGSKYKTFVAKIITNHS
DGTVLGVHLLGDNAPEIIQGVGICLKLNAKISDFYNTIGVHPTSAEELCSMRTPSYYYVK
GEKMEKPSEASL
|
|
|
|---|
| BDBM50178810 |
|---|
| n/a |
|---|
| Name | BDBM50178810 |
|---|
| Synonyms: | CHEMBL371088 | N-(5-chloro-2-(phenylthio)phenyl)butyramide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H16ClNOS |
|---|
| Mol. Mass. | 305.822 |
|---|
| SMILES | CCCC(=O)Nc1cc(Cl)ccc1Sc1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
