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TargetDNA topoisomerase 4 subunit A
LigandBDBM50178882
Substrate/Competitorn/a
Meas. Tech.ChEMBL_338453 (CHEMBL865343)
IC50 3500±n/a nM
Citation Wiles, JASong, YWang, QLucien, EHashimoto, ACheng, JMarlor, CWOu, YPodos, SDThanassi, JAThoma, CLDeshpande, MPucci, MJBradbury, BJ Biological evaluation of isothiazoloquinolones containing aromatic heterocycles at the 7-position: In vitro activity of a series of potent antibacterial agents that are effective against methicillin-resistant Staphylococcus aureus. Bioorg Med Chem Lett16:1277-81 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
DNA topoisomerase 4 subunit A
Name:DNA topoisomerase 4 subunit A
Synonyms:PARC_STAAU | Topoisomerase IV subunit A | grlA | parC
Type:PROTEIN
Mol. Mass.:91040.14
Organism:Staphylococcus aureus
Description:ChEMBL_340188
Residue:800
Sequence:
MSEIIQDLSLEDVLGDRFGRYSKYIIQERALPDVRDGLKPVQRRILYAMYSSGNTHDKNF
RKSAKTVGDVIGQYHPHGDFSVYKAMVRLSQDWKLRHVLIEMHGNNGSIDNDPPAAMRYT
EAKLSLLAEELLRDINKETVSFIPNYDDTTLEPMVLPSRFPNLLVNGSTGISAGYATDIP
PHNLAEVIQATLKYIDNPDITVNQLMKYIKGPDFPTGGIIQGIDGIKKAYESGKGRIIVR
SKVEEETLRNGRKQLIITEIPYEVNKSSLVKRIDELRADKKVDGIVEVRDETDRTGLRIA
IELKKDVNSESIKNYLYKNSDLQISYNFNMVAISDGRPKLMGIRQIIDSYLNHQIEVVAN
RTKFELDNAEKRMHIVEGLIKALSILDKVIELIRSSKNKRDAKENLIEVFEFTEEQAEAI
VMLQLYRLTNTDIVALEGEHKELEALIKQLRHILDNHDALLNVIKEELNEIKKKFKSERL
SLIEAEIEEIKIDKEVMVPSEEVILSMTRHGYIKRTSIRSFNASGVEDIGLKDGDSLLKH
QEVNTQDTVLVFTNKGRYLFIPVHKLADIRWKELGQHVSQIVPIEEDEVVINVFNEKDFN
TDAFYVFATQNGMIKKSTVPLFKTTRFNKPLIATKVKENDDLISVMRFEKDQLITVITNK
GMSLTYNTSELSDTGLRAAGVKSINLKAEDFVVMTEGVSENDTILMATQRGSLKRISFKI
LQVAKRAQRGITLLKELKKNPHRIVAAHVVTGEHSQYTLYSKSNEEHGLINDIHKSEQYT
NGSFIVDTDDFGEVIDMYIS
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  Blast E-value cutoff:
BDBM50178882
n/a
NameBDBM50178882
Synonyms:9-cyclopropyl-6-fluoro-7-(2-methylpyridin-3-yl)isothiazolo[5,4-b]quinoline-3,4(2H,9H)-dione | CHEMBL379022
TypeSmall organic molecule
Emp. Form.C19H14FN3O2S
Mol. Mass.367.397
SMILESCc1ncccc1-c1cc2n(C3CC3)c3s[nH]c(=O)c3c(=O)c2cc1F
Structure
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