Reaction Details |
| Report a problem with these data |
Target | DNA topoisomerase 4 subunit A |
---|
Ligand | BDBM50178882 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_338453 (CHEMBL865343) |
---|
IC50 | 3500±n/a nM |
---|
Citation | Wiles, JA; Song, Y; Wang, Q; Lucien, E; Hashimoto, A; Cheng, J; Marlor, CW; Ou, Y; Podos, SD; Thanassi, JA; Thoma, CL; Deshpande, M; Pucci, MJ; Bradbury, BJ Biological evaluation of isothiazoloquinolones containing aromatic heterocycles at the 7-position: In vitro activity of a series of potent antibacterial agents that are effective against methicillin-resistant Staphylococcus aureus. Bioorg Med Chem Lett16:1277-81 (2006) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
DNA topoisomerase 4 subunit A |
---|
Name: | DNA topoisomerase 4 subunit A |
Synonyms: | PARC_STAAU | Topoisomerase IV subunit A | grlA | parC |
Type: | PROTEIN |
Mol. Mass.: | 91040.14 |
Organism: | Staphylococcus aureus |
Description: | ChEMBL_340188 |
Residue: | 800 |
Sequence: | MSEIIQDLSLEDVLGDRFGRYSKYIIQERALPDVRDGLKPVQRRILYAMYSSGNTHDKNF
RKSAKTVGDVIGQYHPHGDFSVYKAMVRLSQDWKLRHVLIEMHGNNGSIDNDPPAAMRYT
EAKLSLLAEELLRDINKETVSFIPNYDDTTLEPMVLPSRFPNLLVNGSTGISAGYATDIP
PHNLAEVIQATLKYIDNPDITVNQLMKYIKGPDFPTGGIIQGIDGIKKAYESGKGRIIVR
SKVEEETLRNGRKQLIITEIPYEVNKSSLVKRIDELRADKKVDGIVEVRDETDRTGLRIA
IELKKDVNSESIKNYLYKNSDLQISYNFNMVAISDGRPKLMGIRQIIDSYLNHQIEVVAN
RTKFELDNAEKRMHIVEGLIKALSILDKVIELIRSSKNKRDAKENLIEVFEFTEEQAEAI
VMLQLYRLTNTDIVALEGEHKELEALIKQLRHILDNHDALLNVIKEELNEIKKKFKSERL
SLIEAEIEEIKIDKEVMVPSEEVILSMTRHGYIKRTSIRSFNASGVEDIGLKDGDSLLKH
QEVNTQDTVLVFTNKGRYLFIPVHKLADIRWKELGQHVSQIVPIEEDEVVINVFNEKDFN
TDAFYVFATQNGMIKKSTVPLFKTTRFNKPLIATKVKENDDLISVMRFEKDQLITVITNK
GMSLTYNTSELSDTGLRAAGVKSINLKAEDFVVMTEGVSENDTILMATQRGSLKRISFKI
LQVAKRAQRGITLLKELKKNPHRIVAAHVVTGEHSQYTLYSKSNEEHGLINDIHKSEQYT
NGSFIVDTDDFGEVIDMYIS
|
|
|
BDBM50178882 |
---|
n/a |
---|
Name | BDBM50178882 |
Synonyms: | 9-cyclopropyl-6-fluoro-7-(2-methylpyridin-3-yl)isothiazolo[5,4-b]quinoline-3,4(2H,9H)-dione | CHEMBL379022 |
Type | Small organic molecule |
Emp. Form. | C19H14FN3O2S |
Mol. Mass. | 367.397 |
SMILES | Cc1ncccc1-c1cc2n(C3CC3)c3s[nH]c(=O)c3c(=O)c2cc1F |
Structure |
|